Longitudinal exposure to pyrethroids (3-PBA and trans-DCCA) and 2,4-D herbicide in rural schoolchildren of Maule region, Chile.

Autor: Muñoz-Quezada MT; The Neuropsychology and Cognitive Neurosciences Research Center, Faculty of Health Sciences, Universidad Católica del Maule, Talca, Chile. Electronic address: mtmunoz@ucm.cl., Lucero BA; The Neuropsychology and Cognitive Neurosciences Research Center, Faculty of Health Sciences, Universidad Católica del Maule, Talca, Chile., Gutiérrez-Jara JP; Centro de Investigación de Estudios Avanzados del Maule, Universidad Católica del Maule, Chile., Buralli RJ; Departamento de Saúde Ambiental, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil., Zúñiga-Venegas L; The Neuropsychology and Cognitive Neurosciences Research Center, Faculty of Health Sciences, Universidad Católica del Maule, Talca, Chile; Centro de Investigación de Estudios Avanzados del Maule, Universidad Católica del Maule, Chile; Faculty of Medicine, Universidad Católica del Maule, Chile., Muñoz MP; School of Public Health, Faculty of Medicine, Universidad de Chile, Santiago, Chile., Ponce KV; Faculty of Basic Sciences, Universidad Católica del Maule, Chile., Iglesias V; School of Public Health, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2020 Dec 20; Vol. 749, pp. 141512. Date of Electronic Publication: 2020 Aug 04.
DOI: 10.1016/j.scitotenv.2020.141512
Abstrakt: Background: Several studies showed that early exposure to pesticides affects the development and health of children. In Maule, there is previous evidence of the high exposure to organophosphate pesticides (OP) of schoolchildren. However, to date, there are no studies assessing exposure to pyrethroids and the herbicide 2,4-D. Objetive. To evaluate children's exposure to pyrethroids insecticides 3-phenoxybenzoic acid (3-PBA), trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA) and 2,4 dichlorophenoxyacetic acid (2,4-D) herbicides.
Method: Longitudinal study with 48 schoolchildren from two rural schools in the Maule region, Chile. Urinary metabolites of pyrethroids 3-PBA, Trans-DCCA and 2,4-D herbicides were evaluated in 2016 and 2017. Mann-Whitney U for repeated measurements and Spearman's rho correlation tests were used for data analysis. Also, we used a system of impulsive differential equations for mathematical modeling.
Results: All the schoolchildren assessed had more than two pesticide urinary metabolites in both years, with the 3-PBA metabolite being the most frequent. There was an increase in concentrations of urinary 3-PBA in November 2017, compared to 2016 (from 0.69 μg/L to 1.90 μg/L). In 2016, the specific metabolites of 3-PBA were correlated with Trans-DCCA, 2,4-D, chlorpyrifos, diazinon, and para-nitrophenol. In 2017, 3-PBA was correlated with 2,4-D, and Trans-DCCA. The concentrations of 3-PBA of Chilean children were higher than studies conducted in the USA that found an association of prenatal exposure to these metabolites with cognitive difficulties.
Conclusions: We found high concentrations of pyrethroid metabolites among all the schoolchildren assessed, which may impact on their health and development. These insecticides had received no attention from the scientific community in Chile, and neither from the government agencies, despite the increased use of these chemicals in recent years. This is the first study in South America that confirms the exposure to pyrethroids and herbicides through biomarkers in human population living near farm fields.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Financial disclosure All authors have no financial interest in disclosing this article.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: