The corneal effects of intravitreal dexamethasone implantation.
| Autor: | Bayat AH; Department of Ophthalmology, Esenler Hospital, Medipol University, APT: 5 Bahceler, AVE Esenler, Istanbul 34250, Turkey., Karataş G; Department of Ophthalmology, Okmeydanı Research &Traning Hospital, University of Health Sciences, İstanbul, Turkey., Kurt MM; Department of Ophthalmology, Samsun Gazi State Hospital, Samsun, Turkey., Elçioğlu MN; Department of Ophthalmology, Okmeydanı Research &Traning Hospital, University of Health Sciences, İstanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Therapeutic advances in ophthalmology [Ther Adv Ophthalmol] 2020 Aug 06; Vol. 12, pp. 2515841420947544. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2020). |
| DOI: | 10.1177/2515841420947544 |
| Abstrakt: | Objectives: To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy. Material and Methods: 27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in this study. Sirius topography and EM-3000 specular microscopic examinations were performed at the initial examination (baseline), and then on the first day, during the first week, and 1 month after IDI. Changes in corneal parameters were investigated. Results: The mean age was 58.66 ± 6.59 years. 15 patients were men, and 12 were women. The mean disease duration was 12.2 ± 2.4 months, and mean glycosylated hemoglobin (HbA1c) was 7.2 ± 1.1. After dexamethasone injection, the mean central corneal thickness, endothelial cell density, and coefficient variation of cell area presented a statistically significant decrease ( p < 0.05). Anterior segment parameters, such as anterior chamber depth, iridocorneal angle, sim K1 and K2 keratometry, pupillary diameter, horizontal visible iris diameter, and corneal astigmatism did not change ( p > 0.05). Conclusion: Intravitreal dexamethasone implantation affects corneal endothelial cell structure but does not appear to affect corneal topography parameters. Competing Interests: Conflict of interest statement: The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2020.) |
| Databáze: | MEDLINE |
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