Effect of Rectal Ozone (O 3 ) in Severe COVID-19 Pneumonia: Preliminary Results.

Autor: Fernández-Cuadros ME; Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, Spain.; Servicio de Medicina Física y Rehabilitación, Hospital Universitario Santa Cristina, Calle del Maestro Vives 2 y 3, CP28009 Madrid, Spain., Albaladejo-Florín MJ; Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, Spain., Álava-Rabasa S; Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, Spain., Usandizaga-Elio I; Servicio de Medicina Interna, Hospital Universitario Santa Cristina, Madrid, Spain., Martinez-Quintanilla Jimenez D; Servicio de Reumatología, Hospital Universitario Santa Cristina, Madrid, Spain., Peña-Lora D; Unidad de Geriatría, Hospital Universitario Santa Cristina, Madrid, Spain., Neira-Borrajo I; Servicio de Traumatología y Ortopedia, Hospital Universitario Santa Cristina, Madrid, Spain., López-Muñoz MJ; Servicio de Farmacia Hospitalaria, Hospital Universitario Santa Cristina, Madrid, Spain., Rodríguez-de-Cía J; Servicio de Laboratorio Clínico, Hospital Universitario Santa Cristina, Madrid, Spain., Pérez-Moro OS; Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, Spain.
Jazyk: angličtina
Zdroj: SN comprehensive clinical medicine [SN Compr Clin Med] 2020; Vol. 2 (9), pp. 1328-1336. Date of Electronic Publication: 2020 Aug 03.
DOI: 10.1007/s42399-020-00374-1
Abstrakt: The aim of this study is to evaluate the effectiveness of rectal ozone (O 3 ) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with rectal ozone and confirmed with (+) RT-PCR for SARS-CoV-2 and evaluated afterwards. The analyzed outcome variables were as follows: (a) clinical improvement (O 2 saturation and O 2 supply); (b) biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP); (c) radiological improvement. The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. The Protocol was previously approved by the Hospital's Health Care Ethics Committee (CEAS) (Report 15/4/2020) for compassionate use in the face of this exceptional pandemic situation, and prior informed consent was obtained from the patient/legal representative. The patients improved oxygen saturation, as observed by the lower number of desaturations and the lower supply of O 2 . Biomarkers of inflammation decreased (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP). Finally, the radiological signs of bilateral viral pneumonitis improved between 1 and 2 grades based on Taylor's radiological scale. Rectal ozone decreases O 2 supply and improves O 2 saturation, decreases inflammation biomarkers, and improves Taylor's radiological grade in patients with severe COVID-19 pneumonia. Rectal ozone is a safe, effective, cheap, and simple alternative capable of acting on the SARS-CoV-2 virus, and it is presented as an adjunctive therapeutic option to consider in the management of severe bilateral COVID-19 pneumonia.
Competing Interests: Conflict of InterestThe authors declare that they have no conflict of interest.
(© Springer Nature Switzerland AG 2020.)
Databáze: MEDLINE
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