Antiviral potential of garlic ( Allium sativum ) and its organosulfur compounds: A systematic update of pre-clinical and clinical data.

Autor: Rouf R; Department of Pharmacy, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, 8100, Bangladesh., Uddin SJ; Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam.; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Viet Nam., Sarker DK; Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh., Islam MT; Department of Pharmacy, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj, 8100, Bangladesh., Ali ES; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611, USA., Shilpi JA; Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh., Nahar L; Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK., Tiralongo E; School of Pharmacy and Pharmacology, Griffith University, Southport, Qld, Australia., Sarker SD; Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
Jazyk: angličtina
Zdroj: Trends in food science & technology [Trends Food Sci Technol] 2020 Oct; Vol. 104, pp. 219-234. Date of Electronic Publication: 2020 Aug 19.
DOI: 10.1016/j.tifs.2020.08.006
Abstrakt: Background: Garlic ( Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its antiviral effects and the underlying molecular mechanisms exists.
Scope and Approach: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review.
Key Findings and Conclusions: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.
(© 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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