Laser Flare Photometry: A Useful Tool for Monitoring Patients with Juvenile Idiopathic Arthritis-associated Uveitis.

Autor: Orès R; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France.; Department of Ophthalmology, Quinze-Vingts National Eye Hospital, DHU View Restore, INSERM-DHOS CIC, Sorbonne Universités, UPMC Paris VI University, Paris, France., Terrada C; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France.; Sorbonne University, UPMC University Paris 06, Paris, France., Errera MH; Department of Ophthalmology, Quinze-Vingts National Eye Hospital, DHU View Restore, INSERM-DHOS CIC, Sorbonne Universités, UPMC Paris VI University, Paris, France.; Sorbonne University, UPMC University Paris 06, Paris, France., Thorne JE; Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Doukhan R; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France., Cassoux N; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France.; Sorbonne University, UPMC University Paris 06, Paris, France.; Department of Ophthalmology, Curie Institute, Paris, France., Penaud B; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France., LeHoang P; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France.; Sorbonne University, UPMC University Paris 06, Paris, France., Quartier PM; Imagine Institute, Paris Descartes University, Paris, France.; Necker Hospital for Sick Children, Pediatric Hematology-Immunology and Rheumatology Unit, AP-HP, Paris, France., Bodaghi B; Department of Ophthalmology, La Pitié-Salpétrière Hospital, DHU View Restore, Paris, France.; Sorbonne University, UPMC University Paris 06, Paris, France.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2022 Jan 02; Vol. 30 (1), pp. 118-128. Date of Electronic Publication: 2020 Aug 24.
DOI: 10.1080/09273948.2020.1792511
Abstrakt: Purpose: We evaluated laser flare photometry (LFP) values in patients with juvenile idiopathic arthritis (JIA)-associated uveitis.
Methods: Retrospective study. A decrease of the LFP value between baseline visit and 1 month after anti-inflammatory treatment intensification allowed us to define two groups of patients: group 1 (decreased LFP value ≥50%) and group 2 (<50%). We evaluated the prevalence of vision-threatening complications in both groups.
Results: Fifty-four patients (87 eyes) were followed for 9.9 ± 5 years. Group 1 eyes (n = 54) had significantly fewer ocular complications than group 2 eyes (n = 33) at both 5 years visit ( p = .03) and final visit ( p = .047). At the final visit, group 2 eyes had significantly more band keratopathy, trabeculectomy, cataract surgery, glaucoma and papille edema. Group 1 eyes kept a better visual acuity ( p < .0001).
Conclusion: The decrease of LFP values ≥50% of the initial value 1 month after treatment intensification is a good early prognostic factor.
Databáze: MEDLINE
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