| Autor: |
Filho JMM; Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, São Luis, Brazil., Neto JN; Department of Medicine I, Federal University of Maranhão, São Luis, Brazil., Gomes LMRS; Department of Medicine I, Federal University of Maranhão, São Luis, Brazil., Ramos ISF; Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, São Luis, Brazil., Oliveira SSR; Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, São Luis, Brazil., Melo GCF; Department of Medicine, Ceuma University, São Luis, Brazil., Silva LA; Department of Pathology, Federal University of Maranhão, São Luis, Brazil., Moura ECR; Department of Medicine I, Federal University of Maranhão, São Luis, Brazil., Leal PDC; Department of Medicine I, Federal University of Maranhão, São Luis, Brazil. |
| Abstrakt: |
Endometriosis was induced (autotransplant) in Wistar rats. After 21 days, the rats were randomly divided into two groups (16 female rats each). Control group was forced-fed 0.9% sodium chloride solution, and the ginger group was forced-fed 0.5 mg/100 g of Zingiber officinale Roscoe fresh extract, both by gavage, for 14 days, in addition to their normal diet. After that, an anesthetic dose (ketamine/xylazine) was administered until euthanasia. Peritoneal lavage fluid was collected to evaluate tumor necrosis factor (TNF)- α and interleukin (IL)-6, and autotransplant was measured and excised to evaluate histology. The final mean volumes were larger in the control group (120.92 mm 3 ± 78.91) than in the ginger group (40.50 mm 3 ± 19.57) ( P = .01). The endometriosis foci increased in the control group from 45.10 mm 3 ± 29.96 at 21 days postimplantation to 120.92 mm 3 ± 78.91 on the day of euthanasia ( P = .02). In the ginger group, a slight increase was observed from 38.43 mm 3 ± 19.96 to 40.50 mm 3 ± 19.57, without statistical difference ( P = .83). In addition, a greater increase in growth of the endometriosis foci was found when compared with the control (75.81 mm 3 ± 58.95) and ginger groups (2.07 mm 3 ± 18.87) ( P = .004). No difference was found in TNF- α ( P = .51) and in IL-6 ( P = .12). The degree of lesion atrophy was higher in the ginger group (1 ± 0.92) than in the control group (2.25 ± 1.16) ( P = .03). The ginger extract reduced and atrophied autotransplanted endometriosis foci, but did not reduce IL-6 and TNF- α in the peritoneal lavage fluid. |
