Incidental early diagnosis of biphasic pulmonary blastoma in a patient with history of stage IV lung adenocarcinoma.

Autor: Kim K; Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA., Gupta S; Department of Internal Medicine, Tower Health Reading Hospital, West Reading, Pennsylvania, USA., Gupta S; Department of Hematology/Oncology, Einstein Medical Center, Philadelphia, Pennsylvania, USA., Mittar P; Department of Hematology/Oncology, Einstein Medical Center, Philadelphia, Pennsylvania, USA., Minimo C; Department of Pathology, Einstein Medical Center, Philadelphia, Pennsylvania, USA., Tester W; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Thoracic cancer [Thorac Cancer] 2020 Oct; Vol. 11 (10), pp. 3029-3033. Date of Electronic Publication: 2020 Aug 24.
DOI: 10.1111/1759-7714.13629
Abstrakt: Biphasic pulmonary blastoma is a rare but lethal type of lung malignancy with characteristic histology of both epithelial and mesenchymal components. Previously reported cases have been limited to presentation at advanced stages, suggesting that the clinical course of the disease is usually aggressive. Here, we report a case of incidental diagnosis of biphasic pulmonary blastoma by imaging surveillance in a patient previously treated for adenocarcinoma of the lung. The patient was diagnosed with stage 1 disease and underwent successful resection. Next-generation sequencing (NGS) revealed a high mutation burden, a finding not previously reported in a patient with biphasic pulmonary blastoma.
(© 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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