Nucleotide-Selective Templated Self-Assembly of Nanoreactors under Dissipative Conditions.

Autor: Chandrabhas S; Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy., Maiti S; Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Mohali Knowledge City, Manauli, 140306, India., Fortunati I; Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy., Ferrante C; Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy., Gabrielli L; Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy., Prins LJ; Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Dec 01; Vol. 59 (49), pp. 22223-22229. Date of Electronic Publication: 2020 Sep 29.
DOI: 10.1002/anie.202010199
Abstrakt: Nature adopts complex chemical networks to finely tune biochemical processes. Indeed, small biomolecules play a key role in regulating the flux of metabolic pathways. Chemistry, which was traditionally focused on reactions in simple mixtures, is dedicating increasing attention to the network reactivity of highly complex synthetic systems, able to display new kinetic phenomena. Herein, we show that the addition of monophosphate nucleosides to a mixture of amphiphiles and reagents leads to the selective templated formation of self-assembled structures, which can accelerate a reaction between two hydrophobic reactants. The correct matching between nucleotide and the amphiphile head group is fundamental for the selective formation of the assemblies and for the consequent up-regulation of the chemical reaction. Transient stability of the nanoreactors is obtained under dissipative conditions, driven by enzymatic dephosphorylation of the templating nucleotides. These results show that small molecules can play a key role in modulating network reactivity, by selectively templating self-assembled structures that are able to up-regulate chemical reaction pathways.
(© 2020 Wiley-VCH GmbH.)
Databáze: MEDLINE
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