Applications of Mesoporous Silica-Encapsulated Gold Nanorods Loaded Doxorubicin in Chemo-photothermal Therapy.

Autor: Ha Lien NT; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., Phan AD; Faculty of Materials Science and Engineering, Phenikaa Institute for Advanced Study, Phenikaa University, Hanoi 12116, Vietnam.; Faculty of Information Technology, Artificial Intelligence Laboratory, Phenikaa University, Hanoi 12116, Vietnam., Van Khanh BT; College of Science, Vietnam National University (VNU), Hanoi, 334 Nguyen Trai Road, Thanh Xuan, Hanoi 10000, Vietnam., Thuy NT; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., Trong Nghia N; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., My Nhung HT; College of Science, Vietnam National University (VNU), Hanoi, 334 Nguyen Trai Road, Thanh Xuan, Hanoi 10000, Vietnam., Hong Nhung T; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., Quang Hoa D; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., Duong V; Center for Quantum and Electronics, Institute of Physics, VAST, Dao Tan 10, Hanoi 10000, Vietnam., Minh Hue N; Department of Physics, Le Quy Don Technical University, Cau Giay, Hanoi 10000, Vietnam.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2020 Aug 07; Vol. 5 (32), pp. 20231-20237. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
DOI: 10.1021/acsomega.0c01939
Abstrakt: We investigate the chemo-photothermal effects of gold nanorods (GNRs) coated using mesoporous silica (mSiO 2 ) loading doxorubicin (DOX). When the mesoporous silica layer is embedded by doxorubicin drugs, a significant change in absorption spectra enables to quantify the drug loading. We carried out photothermal experiments on saline and livers of mice having GNRs@mSiO 2 and GNRs@mSiO 2 -DOX. We also injected the gold nanostructures into many tumor-implanted mice and used laser illumination on some of them. By measuring the weight and size of tumors, the distinct efficiency of photothermal therapy and chemotherapy on treatment is determined. We experimentally confirm the accumulation of gold nanostructures in the liver.
Competing Interests: The authors declare no competing financial interest.
(Copyright © 2020 American Chemical Society.)
Databáze: MEDLINE
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