Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

Autor: Di Credico G; Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy., Polesel J; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. polesel@cro.it., Dal Maso L; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy. epidemiology@cro.it., Pauli F; Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy., Torelli N; Department of Economics, Business, Mathematics and Statistics, University of Trieste, Trieste, Italy., Luce D; Université de Rennes, INSERM, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, Pointe-à-Pitre, France., Radoï L; INSERM UMR 1018, Centre for Research in Epidemiology and Population Health (CESP), Cancer Epidemiology, Genes and Environment Team, Villejuif, France., Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Serraino D; Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Brennan P; International Agency for Research on Cancer, Lyon, France., Holcatova I; Institute of Hygiene & Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Ahrens W; Leibniz Institute for Prevention Research and Epidemiology, BIPS, Bremen, Germany.; University of Bremen, Faculty of Mathematics and Computer Science, Bremen, Germany., Lagiou P; Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Canova C; University of Padua, Padova, Italy., Richiardi L; Department of Medical Sciences, University of Turin, Turin, Italy., Healy CM; Trinity College School of Dental Science, Dublin, Ireland., Kjaerheim K; Cancer Registry of Norway, Oslo, Norway., Conway DI; School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK., Macfarlane GJ; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK., Thomson P; University of Hong Kong, Hong Kong, China., Agudo A; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, 08908, Spain., Znaor A; International Agency for Research on Cancer, Lyon, France., Franceschi S; Scientific Directorate, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy., Herrero R; International Agency for Research on Cancer, Lyon, France., Toporcov TN; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil., Moyses RA; Head and Neck Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil., Muscat J; Penn State College of Medicine, Hershey, PA, USA., Negri E; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy., Vilensky M; Instituto de Oncología Ángel H. Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina., Fernandez L; Institute of Oncology and Radiobiology, Havana, Cuba., Curado MP; Epidemiology-CIPE/ACCAMARGO, Sao Paulo, Brazil., Menezes A; Universidade Federal de Pelotas, Pelotas, Brazil., Daudt AW; Hospital Moinhos de Vento, Porto Alegre, Brazil., Koifman R; Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil., Wunsch-Filho V; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil., Olshan AF; Department of Epidemiology, Gillings School of Global Public Health, Chapel Hill, NC, USA., Zevallos JP; Division of Head and Neck Surgical Oncology in the Department of Otolaryngology/Head and Neck Surgery at Washington University School of Medicine, St Louis, MO, USA., Sturgis EM; Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA., Li G; Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA., Levi F; Institut Universitaire de Médecine Sociale et Préventive (IUMSP), Unisanté, University of Lausanne, Lausanne, Switzerland., Zhang ZF; UCLA School of Public Health, Los Angeles, CA, USA., Morgenstern H; Departments of Epidemiology and Environmental Health Sciences, School of Public Health and Department of Urology, Medical School, University of Michigan, Ann Arbor, MI, USA., Smith E; College of Public Health, University of Iowa, Iowa City, IA, USA., Lazarus P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA., La Vecchia C; Branch of Medical Statistics, Biometry and Epidemiology 'G. A. Maccacaro', Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy., Garavello W; Department of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Chen C; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Schwartz SM; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Zheng T; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA., Vaughan TL; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kelsey K; Brown University, Providence, Rhode Island, RI, USA., McClean M; Boston University School of Public Health, Boston, MA, USA., Benhamou S; National Institute of Health and Medical Research, INSERM U1018, Villejuif, France., Hayes RB; Division of Epidemiology, New York University School Of Medicine, New York, NY, USA., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Gillison M; 'Thoracic/Head and Neck Medical Oncology', The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Schantz S; New York Eye and Ear Infirmary, New York, NY, USA., Yu GP; Medical Informatics Center, Peking University, Beijing, China., Chuang SC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hashibe M; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA., Yuan-Chin AL; Division of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA., Edefonti V; Branch of Medical Statistics, Biometry and Epidemiology 'G. A. Maccacaro', Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2020 Oct; Vol. 123 (9), pp. 1456-1463. Date of Electronic Publication: 2020 Aug 24.
DOI: 10.1038/s41416-020-01031-z
Abstrakt: Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.
Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.
Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).
Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Databáze: MEDLINE
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