Hybrid cellulose nanocrystal/magnetite glucose biosensors.

Autor: Tracey CT; ITMO University, 9 Lomonosova Street, 191002, St. Petersburg, Russia. Electronic address: traceychantal@gmail.com., Torlopov MA; Institute of Chemistry of Federal Research Centre 'Кomi Science Centre of the Ural Branch of the Russian Academy of Sciences', 48 Pervomayskaya Street, 167000, Syktyvkar, Russia. Electronic address: tanlan799@gmail.com., Martakov IS; Institute of Chemistry of Federal Research Centre 'Кomi Science Centre of the Ural Branch of the Russian Academy of Sciences', 48 Pervomayskaya Street, 167000, Syktyvkar, Russia. Electronic address: gmartakov@gmail.com., Vdovichenko EA; ITMO University, 9 Lomonosova Street, 191002, St. Petersburg, Russia. Electronic address: vdovichenko@scamt-itmo.ru., Zhukov M; ITMO University, 9 Lomonosova Street, 191002, St. Petersburg, Russia; Institute for Analytical Instrumentation RAS, Laboratory of Scanning Probe Microscopy and Spectroscopy, 31 - 33 Ivana Chernykh Street, Lit. A, 198095, St. Petersburg, Russia. Electronic address: cloudjyk@yandex.ru., Krivoshapkin PV; ITMO University, 9 Lomonosova Street, 191002, St. Petersburg, Russia. Electronic address: krivoshapkin@scamt-itmo.ru., Mikhaylov VI; Institute of Chemistry of Federal Research Centre 'Кomi Science Centre of the Ural Branch of the Russian Academy of Sciences', 48 Pervomayskaya Street, 167000, Syktyvkar, Russia. Electronic address: system14@rambler.ru., Krivoshapkina EF; ITMO University, 9 Lomonosova Street, 191002, St. Petersburg, Russia; Institute of Chemistry of Federal Research Centre 'Кomi Science Centre of the Ural Branch of the Russian Academy of Sciences', 48 Pervomayskaya Street, 167000, Syktyvkar, Russia. Electronic address: chemicalfox@mail.ru.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2020 Nov 01; Vol. 247, pp. 116704. Date of Electronic Publication: 2020 Jul 01.
DOI: 10.1016/j.carbpol.2020.116704
Abstrakt: There exists a high demand for simple and affordable blood glucose monitoring methods. For this purpose, new generations of biosensors are being developed for possible in vivo or dermal use. We present (non)sulphated cellulose nanocrystal/magnetite thin films to act as dermal and oral glucose biosensors. The biocompatible (N-CNC)-Fe 3 O 4 and (S-CNC)-Fe 3 O 4 hybrid systems exhibit peroxidase-like activity, indicated by an almost instant color change when in the presence of glucose and ABTS. Both types of biosensors detect glucose concentrations as low as 5 mM (which corresponds to the level of glucose in biological fluids), with (S-CNC)-Fe 3 O 4 being 1.5 - 2 times as sensitive as (N-CNC)-Fe 3 O 4 . Hybrid catalytic activity is more pronounced at room temperature and in acidic environments. The hybrids can therefore be used to determine glucose levels by using sweat and saliva - non-blood bodily secretions which tend to be slightly to moderately acidic and have relatively low glucose levels.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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