Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus.

Autor: Fuenzalida M; Center of Neurobiology and Integrative Physiopathology, Institute of Physiology, Faculty of Science, Universidad de Valparaíso, Chile. Electronic address: marco.fuenzalida@uv.cl., Chiu CQ; Interdisciplinary Center of Neuroscience of Valparaiso, Institute of Neuroscience, Faculty of Science, Universidad de Valparaíso, Chile., Chávez AE; Interdisciplinary Center of Neuroscience of Valparaiso, Institute of Neuroscience, Faculty of Science, Universidad de Valparaíso, Chile.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2021 Feb 21; Vol. 456, pp. 50-59. Date of Electronic Publication: 2020 Aug 20.
DOI: 10.1016/j.neuroscience.2020.08.015
Abstrakt: Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells ("spike-timing-dependent plasticity; STDP") is crucial for the sign and magnitude of long-term changes at many central synapses. Acetylcholine (ACh) via the recruitment of diverse muscarinic receptors is known to influence STDP in a variety of ways, enabling flexibility and adaptability in brain network activity during complex behaviors. In this review, we will summarize and discuss different mechanistic aspects of muscarinic modulation of timing-dependent plasticity at both excitatory and inhibitory synapses in the hippocampus to shape learning and memory.
(Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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