Greater concentrations of IGF-1 are associated with increasing pregnancy rate in melatonin implanted anestrous Barki ewes.

Autor: El-Mokadem MY; Sheep and Goat Research Department, Animal Production Research Institute, Agricultural Research Center, 4 Nadi El-Said, 12311 Dokki, Giza, Egypt., Nour El-Din ANM; Animal Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 22545, Egypt., Ramadan TA; Sheep and Goat Research Department, Animal Production Research Institute, Agricultural Research Center, 4 Nadi El-Said, 12311 Dokki, Giza, Egypt., Taha TA; Animal Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 22545, Egypt. Electronic address: tahaataha@yahoo.com., Samak MA; Animal Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 22545, Egypt., Sharaby MA; Animal Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 22545, Egypt., Rashad AM; Animal Production Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, 22545, Egypt.
Jazyk: angličtina
Zdroj: Animal reproduction science [Anim Reprod Sci] 2020 Aug; Vol. 219, pp. 106542. Date of Electronic Publication: 2020 Jul 13.
DOI: 10.1016/j.anireprosci.2020.106542
Abstrakt: The present study was conducted to determine if increases in IGF-1 concentration, associated with treatment of ewes with melatonin, has beneficial effects on pregnancy rates when there is induction of estrus in anestrous ewes. A total of 120 multiparous lactating ewes were assigned to three groups (n = 10/group). Ewes of Group 1 were treated with a melatonin implant for 42 days followed by insertion of a controlled internal drug release (CIDR) device for 14 days with administration of equine chorionic gonadotropin (eCG) at day of CIDR removal. The ewes of Group 2 were treated with a CIDR and eCG at the same times as ewes of Group 1 and ewes of Group 3 were assigned to an be untreated control group. Melatonin implantation resulted in an increase in IGF-1 concentrations and lesser estradiol (E 2 ) and triiodothyronine (T 3 ) concentrations. Ewes of Groups 1 and 2 had the greatest progesterone (P 4 ) concentration compared ewes of Group 3. The E 2 :P 4 ratio was less in ewes of Group 1 compared Group 3. Melatonin implantation of ewes resulted in a greater pregnancy rate compared to treatment with the CIDR and eCG which, in turn, had a greater rate than ewes of the control group. In conclusion, melatonin implantation modulates the hormonal milieu including P 4 , E 2 , T 3 and IGF-1 in seasonally anestrous ewes. Increased IGF-1concentrations, as a result of melatonin treatment, are associated with a greater percentage pregnancy rate when there is treatment of anestrous ewes to induce onset of estrus.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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