Alcohol intake in Carioca High- and Low-conditioned Freezing rats.

Autor: Bezerra-Karounis MA; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil., Krahe TE; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil., Maisonnette S; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil., Landeira-Fernandez J; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: landeira@puc-rio.br.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Oct; Vol. 197, pp. 173019. Date of Electronic Publication: 2020 Aug 20.
DOI: 10.1016/j.pbb.2020.173019
Abstrakt: Evidence from clinical and epidemiological studies point towards an association between generalized anxiety disorder (GAD) and alcohol abuse. In the present study we investigated whether a similar relationship could be observed in an animal model of GAD. Specifically, we evaluated the alcohol intake of Carioca High- and Low-conditioned Freezing rats (CHF and CLF, respectively). Sex differences in alcohol drinking behavior were also studied. Male and female rats from randomized crossbreeding populations served as controls (CTL). Free- and forced-choice protocols were used to measure alcohol consumption, and quinine and saccharin were used as taste control solutions. Our results indicate that CHF rats consumed more alcohol than CLF and CTL ones in both the free-choice (6 and 10% concentrations) and the forced-choice (10% concentration) conditions. CHF female rats exhibited the highest amount of alcohol intake in the forced-choice condition. CHF females also consumed more quinine than CHF male rats. Finally, CHF rats exhibited lower saccharin consumption compared to CLF and CTL animals. Altogether, these results support the hypothesis that there is a positive relationship between anxiety and alcohol intake, and provide further evidence for the use of CHF rats as a model of GAD.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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