Evaluation of the clinical utility of optical coherence tomography angiography in age-related macular degeneration.

Autor:	Cavichini M; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.; Ophthalmology, Faculdade De Medicina Do ABC, Santo Andre, Brazil., Dans KC; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA., Jhingan M; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.; Aravind Eye Hospital, Madurai, India., Amador-Patarroyo MJ; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.; Ophthalmology, Escuela Superior De Oftalmologia, Instituto Barraquer De America, Bogota, Colombia., Borooah S; Ophthalmology, University of California San Diego, La Jolla, California, USA.; Center for Clinical Brain Sciences, School of Clinical Sciences, the University of Edinburgh, Edinburgh, Scotland, UK., Bartsch DU; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA., Nudleman E; Jacobs Retina Center, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA., Freeman WR; Jacobs Retina Center, Shiley Eye, UCSD, La Jolla, California, USA wrfreeman@health.ucsd.edu.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2021 Jul; Vol. 105 (7), pp. 983-988. Date of Electronic Publication: 2020 Aug 21.
DOI:	10.1136/bjophthalmol-2020-316622
Abstrakt:	Background/aims: To evaluate the ability of optical coherence tomography angiography (OCTA) to identify the presence or absence of choroidal neovascularisation (CNV) and CNV activity in age-related macular degeneration (AMD). Methods: Clinical parameters, fundus fluorescein angiogram and spectral-domain optical coherence tomography (SD-OCT) were used as the gold standard to determine disease activity. OCTA imaging was performed on the same day and was graded by two masked retina specialists for the presence or absence of CNV. Traditional multimodal imaging and OCTA findings were compared. Results: One hundred and fifty-two eyes of 106 patients with AMD were retrospectively reviewed. Of these, 59 eyes had wet AMD and 93 had dry AMD with high-risk drusen. OCTA had 85.4% and 79.3% specificity and sensitivity, respectively, in determining the presence or absence of CNV. OCTA was 69.5% accurate in determining active CNV. False positives and negatives were 21.6% and 8.0%, respectively. Conclusions: This study suggests that en-face OCTA images allow a moderate ability to identify CNV and that OCTA alone is weak at recognising active CNV requiring treatment in AMD. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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