| Autor: |
Aryati A; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia.; Institute of Tropical Diseases, Universitas Airlangga, Surabaya 60115, Indonesia., Wrahatnala BJ; Master Program of Tropical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia., Yohan B; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia., Fanny M; Clinical Pathology Sub-Specialization Program, Universitas Airlangga, Surabaya 60286, Indonesia.; Department of Clinical Pathology, Faculty of Medicine, Universitas Ciputra, Surabaya 60219, Indonesia., Hakim FKN; Master Program of Tropical Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia., Sunari EP; Clinical Pathology Specialization Program, Universitas Airlangga, Surabaya 60286, Indonesia., Zuroidah N; Clinical Pathology Specialization Program, Universitas Airlangga, Surabaya 60286, Indonesia., Wardhani P; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia.; Institute of Tropical Diseases, Universitas Airlangga, Surabaya 60115, Indonesia., Santoso MS; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia., Husada D; Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia., Rohman A; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, Indonesia., Tarmizi SN; Directorate of Vector-Borne and Zoonotic Disease, Ministry of Health of Indonesia, Jakarta 12950, Indonesia., Sievers JTO; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia., Sasmono RT; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia. |
| Abstrakt: |
Outbreaks of dengue virus (DENV) in Indonesia have been mainly caused by the DENV serotype-1; -2; or -3. The DENV-4 was the least-reported serotype in Indonesia during the last five decades. We recently conducted a molecular epidemiology study of dengue in the Jember regency, East Java province, Indonesia. Dengue is endemic in the region and outbreaks occur annually. We investigated the clinical characteristics and etiology of dengue-like febrile illness in this regency to understand the disease dynamics. A total of 191 patients with clinical symptoms similar to dengue were recruited during an 11-month study in 2019-2020. Children accounted for the majority of cases and dengue burden was estimated in 41.4% of the cases based on NS1 antigen, viral RNA, and IgG/IgM antibody detection with the majority (73.4%) being primary infections. Secondary infection was significantly associated with a higher risk of severe dengue manifestation. All four DENV serotypes were detected in Jember. Strikingly, we observed the predominance of DENV-4, followed by DENV-3, DENV-1, and DENV-2. Genotype determination using Envelope gene sequence revealed the classification into Genotype I, Cosmopolitan Genotype, Genotype I, and Genotype II for DENV-1, -2, -3, and -4, respectively. The predominance of DENV-4 in Jember may be associated with a new wave of DENV infections and spread in a non-immune population lacking a herd-immunity to this particular serotype. |
