A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches.

Autor: Cam ME; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul 34722, Turkey; Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey. Electronic address: m.cam@ucl.ac.uk., Hazar-Yavuz AN; Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey., Cesur S; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul 34722, Turkey; Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey., Ozkan O; Department of Metallurgical and Materials Engineering, Faculty of Engineering, Atilim University, 06836 Ankara, Turkey., Alenezi H; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Department of Manufacturing Engineering, College of Technological Studies, PAAET, 13092 Kuwait City, Kuwait., Turkoglu Sasmazel H; Department of Metallurgical and Materials Engineering, Faculty of Engineering, Atilim University, 06836 Ankara, Turkey., Sayip Eroglu M; Department of Chemical Engineering, Marmara University, Faculty of Engineering, Goztepe Campus, 34722 Kadikoy/Istanbul, Turkey; TUBITAK-UME, Chemistry Group Laboratories, 41470 Gebze/Kocaeli, Turkey., Brako F; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK., Ahmed J; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK., Kabasakal L; Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey., Ren G; Mechanical and Mechatronics Engineering Division, School of Engineering and Technology, University of Hertfordshire, UK., Gunduz O; Center for Nanotechnology and Biomaterials Application and Research, Marmara University, Istanbul 34722, Turkey; Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey., Edirisinghe M; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. Electronic address: m.edirisinghe@ucl.ac.uk.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2020 Oct 15; Vol. 588, pp. 119782. Date of Electronic Publication: 2020 Aug 19.
DOI: 10.1016/j.ijpharm.2020.119782
Abstrakt: Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: