Transient risk of ambient fine particulate matter on hourly cardiovascular events in Tainan City, Taiwan.

Autor: Wu PC; Department of Green Energy and Environmental Resources, Chang Jung Christian University, Tainan, Taiwan.; Department of Occupational and Safety and Health, Chang Jung Christian University, Tainan, Taiwan., Cheng TJ; Departments of Neurology and Occupational Medicine, Chi Mei Medical Center, Tainan, Taiwan., Kuo CP; Department of Civil and Environmental Engineering, University of Tennessee Knoxville, Knoxville, Tennessee, United States of America., Fu JS; Department of Civil and Environmental Engineering, University of Tennessee Knoxville, Knoxville, Tennessee, United States of America., Lai HC; Department of Green Energy and Environmental Resources, Chang Jung Christian University, Tainan, Taiwan., Chiu TY; Environmental Research and Information Center, Chang Jung Christian University, Tainan, Taiwan., Lai LW; Environmental Research and Information Center, Chang Jung Christian University, Tainan, Taiwan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2020 Aug 21; Vol. 15 (8), pp. e0238082. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
DOI: 10.1371/journal.pone.0238082
Abstrakt: Background: The association between daily changes in ambient fine particulate matter (PM2.5) and cardiovascular diseases have been well established in mechanistic, epidemiologic and exposure studies. Only a few studies examined the effect of hourly variations in air pollution on triggering cardiovascular events. Whether the current PM2.5 standards can protect vulnerable individuals with chronic cardiovascular diseases remain uncertain.
Methods: we conducted a time-stratified, case-crossover study to assess the associations between hourly changes in PM2.5 levels and the vascular disease onset in residents of Tainan City, Taiwan, visiting Emergency Room of Chi Mei Medical Center between January 2006 and December 2016. There were 26,749 cases including 10,310 females (38.5%) and 16,439 males (61.5%) identified. The time of emergency visit was identified as the onset for each case and control cases were selected as the same times on other days, on the same day of the week in the same month and year respectively. Residential address was used to identify the ambient air pollution exposure concentrations from the closest station. Conditional logistic regression with the stepwise selection method was used to estimate adjusted odds ratios (ORs) for the association.
Results: When we only included cases occurring at PM2.5>10 μg/m3 and PM2.5>25 μg/m3, very significant ORs could be observed for 10 μg/m3 increases in PM2.5 at 0 and 1 hour, implying fine particulate exposure could promptly trigger vascular disease events. Moreover, a very clear increase in risk could be observed with cumulative exposure from 0 to 48 hours, especially in those cases where PM2.5>25 μg/m3.
Conclusions: Our study demonstrated that transient and low concentrations of ambient PM2.5 trigger adult vascular disease events, especially cerebrovascular disease, regardless of age, sex, and exposure timing. Warning and delivery systems should be setup to protect people from these prompt adverse health impacts.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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