Hepatitis B birth vaccination, cohort study, Tunisia 2000-2017.

Autor: Dhouib W; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Kacem M; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Bennasrallah C; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Ben Fredj M; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Abroug H; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Zemni I; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Chelly S; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia., Maalel I; The Regional Direction of Primary Health of Monastir, Minister of Health , Tunisia., Samia GS; The Regional Direction of Primary Health of Monastir, Minister of Health , Tunisia., Belguith Sriha A; Department of Epidemiology and Preventive Medicine, University of Monastir , Monastir, Tunisia.
Jazyk: angličtina
Zdroj: The Libyan journal of medicine [Libyan J Med] 2020 Dec; Vol. 15 (1), pp. 1809223.
DOI: 10.1080/19932820.2020.1809223
Abstrakt: We aimed to compare the efficiency of the first dose of Hepatitis B (HB) vaccine: at Birth versus at 3 months and to evaluate the efficacy of HB vaccine. We conducted a cohort study in the governorate of Monastir. Vaccinated Cohort (VC) included populations receiving the first dose at 3 months (Protocol 1), and at birth (HepB-BD) (Protocol 2). First dose was followed by at least two doses. We collected, from January 2000 to December 2017, cases diagnosed by serological markers (hepatitis B surface antigen (HBsAg) and anti-HBc). We calculated Absolute Risk (AR) per 100,000 PY and the Relative risk reduction (RRR). Twenty-five cases were notified among VC and 1501 cases among not vaccinated cohort (NVC). Twenty-three cases were notified among the cohort receiving the first dose at 3 months and two cases in Protocol 2. The AR per 100,000 PY was 5.67 (CI95%: 3.36-7.99) in Protocol 1 and 0.11 (CI95%: 0.001-0.26) in Protocol 2. The RRR was 77% (95% CI: 66; 85) in Protocol 1 and 99.4% (95% CI: 97.8; 99.9) in Protocol 2. We identified 4 HB cases for children aged between 5 and 11 who benefited from protocol 1 (born between 2000 and 2006) and zero cases for children of the same age group benefiting from protocol 2 (born between 2011 and 2017). The annual number of HB has decreased from 112 in 2000 to 48 in 2017. We predicted 40 new cases of HB in 2030. HepB-BD was 99.4% effective at preventing HB. The continuity of HepB-BD worldwide would achieve WHO's goal of eliminating HB as a threat to health by 2050.
Abbreviations: AR: Absolute Risk; ARR: Absolute Risk Reduction; G1: Group1; G2: Group2; HB: Hepatitis B; HepB-BD: Hepatitis B Birth Dose; MENA: Middle East and North Africa; NNV: Number Needed to Vaccine; HIV: Human Immunodeficiency Virus; NVC: Not Vaccinated Cohort; PY: Person Year; RRR: Relative Risk Reduction; RR: Relative Risk; VC: Vaccinated Cohort; WHO: World Health Organization.
Databáze: MEDLINE
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