The Impact of Deterministic Signal Loss on OCT Angiography Measurements.

Autor:	Czakó C; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., István L; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., Benyó F; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., Élő Á; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., Erdei G; Department of Atomic Physics, Budapest University of Technology and Economics, Budapest, Hungary., Horváth H; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., Nagy ZZ; Department of Ophthalmology, Semmelweis University, Budapest, Hungary., Kovács I; Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2020 Apr 17; Vol. 9 (5), pp. 10. Date of Electronic Publication: 2020 Apr 17 (Print Publication: 2020).
DOI:	10.1167/tvst.9.5.10
Abstrakt:	Purpose: In this study, we aimed at investigating the impact of deterministic signal loss on image quality and, thus, on optical coherence tomography angiography (OCTA) measurements performed by the RTVue-XR Avanti System. Methods: Absorptive filters with different optical densities (ODs) were used to simulate signal loss in a controlled way in 30 eyes from 15 healthy subjects. Scan Quality (SQ), provided by the AngioVue software, was applied as a measure of image quality. Results: Assessing the effect of decreased light transmittance on SQ values as well as that of attenuated image quality on OCTA parameters revealed a strong systematic dependence between these quantities. Attenuated image quality was associated with significantly decreased macular and peripapillary vessel density (VD) values, and we calculated a correction factor of 2.27% to 3.97% for a one-unit change in SQ for the different VD parameters. Conclusions: Our findings suggest that the influence of systematic changes in image quality on OCTA parameters needs to be considered during patient follow-up in order to make valid assessment of progression. Translational Relevance: For accurate evaluation of longitudinal changes in OCTA parameters, equal scan quality or using a correction factor is suggested. Competing Interests: Disclosure: C. Czakó, None; L. István, None; F. Benyó, None; Á. Élő, None; G. Erdei, None; H. Horváth, None; Z.Z. Nagy, None; I. Kovács, None (Copyright 2020 The Authors.)
Databáze:	MEDLINE
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