The correlation between vitamin D levels and demographics in patients with gastrointestinal disorders; a cross-sectional study.

Autor: Ahmad SJ; School of Medicine, University of Buckingham, Buckingham, UK., Ahmed AR; Department of Bariatric and Metabolic Surgery, Imperial College London, London, UK., Ali J; Department of Gastroenterology, Milton Keynes University Hospital, Milton Keynes, UK., Macfaul G; Department of Gastroenterology, Milton Keynes University Hospital, Milton Keynes, UK., Johnson MW; Department of Gastroenterology, Luton & Dunstable Hospital, Luton, UK., Exadaktylos AK; Department of Emergency Medicine, Inselspital, University Hospital of Bern, Bern, Switzerland., Archid R; Department of General, Visceral and Transplant Surgery, Eberhard-Karls-University Hospital Tuebingen, Tuebingen, Germany., Ahmad S; Istishari Private Hospital, Amman, Jordan., Rostami-Nejad M; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohaghegh-Shalmani H; Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Madhotra R; Department of Gastroenterology, Milton Keynes University Hospital, Milton Keynes, UK., Rostami K; Department of Gastroenterology Palmerston North Hospital, New Zealand.
Jazyk: angličtina
Zdroj: Gastroenterology and hepatology from bed to bench [Gastroenterol Hepatol Bed Bench] 2020 Summer; Vol. 13 (3), pp. 223-231.
Abstrakt: Aim: The aim of the present study was to evaluate vitamin D levels, in correlation with age, body mass index (BMI), gender and ethnicity, in patients with gastrointestinal disorders (GID).
Background: Vitamin D deficiency (VDD) is a global health issue, affecting over 1 billion people. A great body of evidence has shown that it can lead to increased morbidity and mortality. Furthermore, latitude, sedentary lifestyle, limited sunlight exposure, ageing and the presence of comorbidities and chronic illnesses, places patients at an increased risk of VDD.
Methods: 305 consecutive patients, with GID, were assessed for vitamin D levels, using a two-step competitive binding immunoenzymatic assay. Patients were then classified as adequate (50-150nmol/l), insufficient (25-50nmol/l) and deficient (<25nmol/l).
Results: 62% of the investigated subjects had low vitamin D levels. From this group, 132 patients (43.3%) had insufficient vitamin D levels, 57 (18.7%) had deficient levels and 116 (38%) had adequate levels. Age was not significantly different in the 3 groups (p=0.29). Interestingly, vitamin D levels were significantly lower in men (39.23±23.62) compared to women (50.68±24.46) (p=0.0001). The BMI was significantly higher in patients with insufficient vitamin D levels. Being of Asian ethnicity had a positive influence on vitamin D levels (B=0.076) (p<0.0001). 71.4% of patients, with IBD, and 60% of patients, with abnormal liver function, had low vitamin D levels.
Conclusion: VDD has a high prevalence in patients with GID in particular IBD and liver disease in the United Kingdom. Routine vitamin D testing and supplementations in the case of deficiency and suboptimal level of vitamin D for patients with hepatobiliary, pancreatic, kidney, malabsorptive and restrictive diseases/surgeries is recommended.
(©2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.)
Databáze: MEDLINE
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