Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.

Autor:	Eyre DW; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom., Lumley SF; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., O'Donnell D; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Campbell M; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Sims E; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Lawson E; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Warren F; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., James T; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Cox S; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Howarth A; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Doherty G; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Hatch SB; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Target Discovery Institute, University of Oxford, Oxford, United Kingdom., Kavanagh J; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Chau KK; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Fowler PW; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Swann J; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Volk D; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Yang-Turner F; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Stoesser N; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at University of Oxford in partnership with Public Health England, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Matthews PC; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Dudareva M; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Davies T; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Shaw RH; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Peto L; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Downs LO; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Vogt A; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Amini A; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Young BC; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Drennan PG; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Mentzer AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Skelly DT; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Karpe F; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Neville MJ; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Andersson M; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Brent AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Jones N; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Martins Ferreira L; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Christott T; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Marsden BD; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Kennedy Institute of Rheumatology Research, University of Oxford, Oxford, United Kingdom., Hoosdally S; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Cornall R; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Crook DW; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Stuart DI; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Screaton G; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Peto TE; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Holthof B; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., O'Donnell AM; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Ebner D; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Target Discovery Institute, University of Oxford, Oxford, United Kingdom., Conlon CP; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Jeffery K; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Walker TM; Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2020 Aug 21; Vol. 9. Date of Electronic Publication: 2020 Aug 21.
DOI:	10.7554/eLife.60675
Abstrakt:	We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]). Competing Interests: DE Lecture fees from Gilead, outside the submitted work, SL, DO, MC, ES, EL, FW, TJ, SC, AH, GD, SH, JK, KC, PF, JS, DV, FY, NS, PM, MD, TD, RS, LP, LD, AV, AA, BY, PD, AM, DS, FK, MN, MA, AB, NJ, LM, TC, BM, SH, RC, DC, DS, GS, TP, BH, AO, DE, CC, KJ, TW No competing interests declared (© 2020, Eyre et al.)
Databáze:	MEDLINE
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