Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats.

Autor:	Handan BA; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil., De Moura CFG; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil., Cardoso CM; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil., Santamarina AB; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil., Pisani LP; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil., Ribeiro DA; Department of Biosciences, Federal University of São Paulo, UNIFESP, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Drug research [Drug Res (Stuttg)] 2020 Nov; Vol. 70 (11), pp. 503-511. Date of Electronic Publication: 2020 Aug 20.
DOI:	10.1055/a-1221-4733
Abstrakt:	Background: The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods: A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results: Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion: Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.)
Databáze:	MEDLINE
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