Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications.

Autor:	Shiel AI; Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, UK., Ayre WN; School of Dentistry, Cardiff University, Cardiff, CF14 4XY, UK., Blom AW; Musculoskeletal Research Unit, University of Bristol, Southmead, Bristol, BS10 5NB, UK., Hallam KR; University of Bristol, Interface Analysis Centre, HH Wills Physics Laboratory, Tyndall Avenue, Bristol, BS8 1TL, UK., Heard PJ; University of Bristol, Interface Analysis Centre, HH Wills Physics Laboratory, Tyndall Avenue, Bristol, BS8 1TL, UK., Payton O; University of Bristol, Interface Analysis Centre, HH Wills Physics Laboratory, Tyndall Avenue, Bristol, BS8 1TL, UK., Picco L; University of Bristol, Interface Analysis Centre, HH Wills Physics Laboratory, Tyndall Avenue, Bristol, BS8 1TL, UK.; Department of Physics, Virginia Commonwealth University, Richmond, 23284, VA, USA., Mansell JP; Department of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, UK.
Jazyk:	angličtina
Zdroj:	Journal of orthopaedic translation [J Orthop Translat] 2020 Jul; Vol. 23, pp. 140-151.
DOI:	10.1016/j.jot.2020.02.002
Abstrakt:	Background: Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone, it is estimated that £137 m is spent annually on revision arthroplasties. Enhancing the longevity of titanium implants will help reduce the incidence and overall cost of failed devices. Methods: In realising the development of a superior titanium technology, we exploited the natural affinity of titanium for phosphonic acids and developed a facile means of coating the metal with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP), a phosphatase-resistant analogue of lysophosphatidic acid (LPA). Importantly LPA and selected LPA analogues like FHBP synergistically cooperate with calcitriol to promote human osteoblast formation and maturation. Results: Herein, we provide evidence that simply immersing titanium in aqueous solutions of FHBP afforded a surface that was superior to unmodified metal at enhancing osteoblast maturation. Importantly, FHBP-functionalised titanium remained stable to 2 years of ambient storage, resisted ∼35 kGy of gamma irradiation and survived implantation into a bone substitute (Sawbone™) and irrigation. Conclusion: The facile step we have taken to modify titanium and the robustness of the final surface finish are appealing properties that are likely to attract the attention of implant manufacturers in the future. The Translational Potential of This Article: We have generated a functionalised titanium (Ti) surface by simply immersing Ti in aqueous solutions of a bioactive lipid. As a facile procedure it will have greater appeal to implant manufacturers compared to onerous and costly developmental processes. Competing Interests: The authors have no conflicts of interest to disclose in relation to this article. (© 2020 The Author(s).)
Databáze:	MEDLINE
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