Objective Quantification of Spontaneous Retinal Venous Pulsations Using a Novel Tablet-Based Ophthalmoscope.

Autor:	Shariflou S; Vision Science Group, Discipline of Orthoptics, Graduate School of Health, University of Technology Sydney, NSW, Australia., Agar A; Vision Science Group, Discipline of Orthoptics, Graduate School of Health, University of Technology Sydney, NSW, Australia.; Ophthalmology Department, Prince of Wales Hospital, Sydney, NSW, Australia.; Department of Ophthalmology, University of New South Wales, Sydney, NSW, Australia.; Marsden Eye Specialists, Sydney, NSW, Australia., Rose K; Vision Science Group, Discipline of Orthoptics, Graduate School of Health, University of Technology Sydney, NSW, Australia., Bowd C; Hamilton Glaucoma Centre, Shiley Eye Institute, University of California, San Diego, San Diego, CA, USA., Golzan SM; Vision Science Group, Discipline of Orthoptics, Graduate School of Health, University of Technology Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2020 Mar 18; Vol. 9 (4), pp. 19. Date of Electronic Publication: 2020 Mar 18 (Print Publication: 2020).
DOI:	10.1167/tvst.9.4.19
Abstrakt:	Purpose: Dynamic assessment of retinal vascular characteristics can aid in identifying glaucoma-specific biomarkers. More specifically, a loss of spontaneous retinal venous pulsations (SVPs) has been reported in glaucoma, but a lack of readily available tools has limited the ability to explore the full potential of SVP analysis in glaucoma assessment. Advancements in smart technology have paved the way for the development of portable, noninvasive, and inexpensive imaging modalities. By combining off-the-shelf optical elements and smart devices, the current study aims to determine whether SVPs can be detected and quantified using a novel tablet-based ophthalmoscope in glaucoma and glaucoma suspects. Methods: Thirty patients, including 21 with confirmed glaucoma (9 men; average age 75 ± 8 years) and 9 glaucoma suspects (5 men; average age 64 ± 9 years), were studied. All patients had intraocular pressure measurements, Humphrey visual field assessment, optical coherence tomography, and a 10-second videoscopy of the retinal circulation. The retinal vasculature recordings (46° field of view at 30 frames per second) were analyzed to extract SVP amplitudes. Results: SVPs were detected and quantified in 100% of patients with glaucoma and those with suspected glaucoma using the novel device. The average SVP amplitudes in glaucoma and glaucoma suspects were 42.6% ± 10.7% and 34% ± 6.7%, respectively. Conclusions: Our results suggest that a novel tablet-based ophthalmoscope can aid in documenting and objectively quantifying SVPs in all patients. Translational Relevance: Outcomes of this study provide an innovative, portable, noninvasive, and inexpensive solution for objective assessment of SVPs, which may have clinical relevance in glaucoma screening. Competing Interests: Disclosure: S. Shariflou, None; A. Agar, None; K. Rose, None; C. Bowd, None; S.M. Golzan, None (Copyright 2020 The Authors.)
Databáze:	MEDLINE
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