Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies.

Autor: Hidaka A; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. akihisahidaka@gmail.com., Harrison TA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Cao Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri.; Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri., Sakoda LC; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Division of Research, Kaiser Permanente Northern California, Oakland, California., Barfield R; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Giannakis M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Song M; Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Phipps AI; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Epidemiology, University of Washington, Seattle, Washington., Figueiredo JC; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California., Zaidi SH; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Toland AE; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Amitay EL; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Borozan I; Ontario Institute for Cancer Research, Toronto, Canada., Chan AT; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Gunter MJ; Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France., Guinter MA; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia., Harlid S; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden., Hampel H; Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Lin Y; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Moreno V; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.; School of Public Health, University of Washington, Seattle, Washington., Nishihara R; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Ogino S; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts., Obón-Santacana M; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Parfrey PS; Memorial University, Faculty of Medicine, Newfoundland, Canada., Potter JD; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Slattery ML; Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Steinfelder RS; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Um CY; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia., Wang X; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Woods MO; Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada., Van Guelpen B; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden., Thibodeau SN; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota., Hoffmeister M; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sun W; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington., Hsu L; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Biostatistics, University of Washington, Seattle, Washington., Buchanan DD; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia.; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia., Campbell PT; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia., Peters U; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Epidemiology, University of Washington, Seattle, Washington.
Jazyk: angličtina
Zdroj: Cancer research [Cancer Res] 2020 Oct 15; Vol. 80 (20), pp. 4578-4590. Date of Electronic Publication: 2020 Aug 14.
DOI: 10.1158/0008-5472.CAN-20-0168
Abstrakt: Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all epidemiologic studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by colorectal cancer molecular subtypes. Here, we investigate the association of fruit, vegetables, and fiber intake with four well-established colorectal cancer molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend toward decreased risk of BRAF -mutated tumors [OR 4th vs. 1st quartile = 0.82 (95% confidence interval, 0.65-1.04)] but not BRAF -wildtype tumors [1.09 (0.97-1.22); P difference as shown in case-only analysis = 0.02]. This difference was observed in case-control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with colorectal cancer risk for cases with microsatellite stable/MSI-low, CIMP-negative, BRAF -wildtype, and KRAS -wildtype tumors ( P trend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-colorectal cancer pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF -mutated, or KRAS -mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and colorectal cancer risk that have previously been reported. SIGNIFICANCE: These analyses by colorectal cancer molecular subtypes potentially explain the inconsistent findings between dietary fruit or fiber intake and overall colorectal cancer risk that have previously been reported.
(©2020 American Association for Cancer Research.)
Databáze: MEDLINE
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