Atypical Outcomes for Hepatitis-associated Acquired Aplastic Anemia: 2 Case Studies and Review of the Literature.

Autor:	Lapinski J; UPMC Children's Hospital of Pittsburgh., Nolfi-Donegan D; UPMC Children's Hospital of Pittsburgh.; University of Pittsburgh School of Medicine, Pittsburgh, PA., Cooper JD; UPMC Children's Hospital of Pittsburgh.; University of Pittsburgh School of Medicine, Pittsburgh, PA., Squires RH; UPMC Children's Hospital of Pittsburgh.; University of Pittsburgh School of Medicine, Pittsburgh, PA.
Jazyk:	angličtina
Zdroj:	Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Jul 01; Vol. 43 (5), pp. 195-199.
DOI:	10.1097/MPH.0000000000001916
Abstrakt:	There is little data specifically dedicated to the long-term outcomes of the hepatitis-associated variant of aplastic anemia (HAAA). A majority of patients with nonsevere (moderate) aplastic anemia progress to severe aplastic anemia, and severe aplastic anemia typically results in death if left untreated. We present 2 unique cases of HAAA that contribute to our knowledge of the natural history of this disease variant. One patient had moderate HAAA that never progressed to severe disease. The second patient had severe HAAA that spontaneously resolved without treatment. The rare possibility of moderate HAAA failing to progress to fulfill severe criteria, or of severe HAAA spontaneously improving, may complicate early treatment decisions for some patients. Competing Interests: The authors declare no conflict of interest. (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu