A potential prognostic marker in primitive lung neuroendocrine tumor: A case report.

Autor:	Russo L; Division of Laboratory Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Grilli B; Division of Laboratory Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Minopoli A; Division of Laboratory Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Capozzi M; Division of Breast Medical Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Tafuto S; Department of Abdominal Oncology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Correra M; Division of Oncology Interventistic Radiology, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Trillò G; Specialization School in Clinical Pathology and Clinical Biochemistry, School of Medicine and Surgery, Università degli Studi di Napoli Federico II, Napoli, Italy., Isgrò MA; Division of Laboratory Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy., Cavalcanti E; Division of Laboratory Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.
Jazyk:	angličtina
Zdroj:	The International journal of biological markers [Int J Biol Markers] 2020 Sep; Vol. 35 (3), pp. 102-106. Date of Electronic Publication: 2020 Aug 20.
DOI:	10.1177/1724600820947107
Abstrakt:	Background: The diagnosis and monitoring of primitive lung neuroendocrine tumors (lung pNETs) are usually performed by the measurement of serum chromogranin A (CgA) and urinary 5-hydroxyindolacetic acid (5-HIAA) levels. However, imaging techniques are necessary due to the poor diagnostic efficiency of the laboratory tests. Methods: A total-body computed tomography and bone scintigraphy scans showed multiple hepatic and bone metastases of a 55-year-old man affected by well-differentiated lung pNETs without severe initial symptoms. After diagnosis, he started therapy and was monitored with serum, urinary markers, and imaging techniques. Results: During follow-up, the urinary 5-HIAA levels did not significantly increase, while serum CgA and urinary para-hydroxyphenylacetic acid (pHPAA) levels (urinary organic acid physiologically present in the urines of healthy subjects) showed significant increases related to worsening clinical condition. Conclusions: The early increase in urinary pHPAA levels-usually not dosed in pNET patient monitoring-could be a promising prognostic marker.
Databáze:	MEDLINE
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