The potential role of pneumococcal conjugate vaccine in reducing acute respiratory inflammation in community-acquired pneumococcal pneumonia.

Autor: Shen CF; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, North Dist, Tainan, 70403, Taiwan.; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan., Wang SM; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan., Chi H; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Department of Pediatrics, Mackay Children's Hospital, Mackay Medical College, Taipei City, Taiwan., Huang YC; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Division of Infectious Diseases, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City, Taiwan., Huang LM; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Department of Pediatrics, National Taiwan University and Hospital, Taipei City, Taiwan., Huang YC; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan., Lin HC; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; College of Medicine, China Medical University, Taichung City, Taiwan.; Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, Taichung City, Taiwan., Ho YH; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Division of Infectious Disease, Department of Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan., Hsiung CA; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan.; Institute of Population Health Sciences, National Health Research Institutes, Zhunan Township, Taiwan., Liu CC; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, North Dist, Tainan, 70403, Taiwan. liucc@mail.ncku.edu.tw.; Taiwan Pediatric Infectious Disease Alliance, Taipei City, Taiwan. liucc@mail.ncku.edu.tw.; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan. liucc@mail.ncku.edu.tw.
Jazyk: angličtina
Zdroj: Journal of biomedical science [J Biomed Sci] 2020 Aug 19; Vol. 27 (1), pp. 88. Date of Electronic Publication: 2020 Aug 19.
DOI: 10.1186/s12929-020-00680-9
Abstrakt: Background: Pneumococcal conjugate vaccine (PCV) reduces both invasive pneumococcal disease (IPD) and other pneumococcal infections worldwide. We investigated the impact of stepwise implementation of childhood PCV programs on the prevalence of pneumococcal pneumonia, severity of acute inflammation, and associations between breakthrough pneumonia and pneumococcal serotypes in Taiwan.
Methods: In total, 983 children diagnosed with community-acquired pneumococcal pneumonia were enrolled between January 2010 and December 2015.
Results: Proportions of pneumococcal vaccinations increased each year in age-stratified groups with PCV7 (32.2%) as the majority, followed by PCV13 (12.2%). The proportion of pneumococcal pneumonia decreased each year in age-stratified groups, especially in 2-5 year group. Serotype 19A is the leading serotype either in vaccinated (6.4%) or unvaccinated patients (5.2%). In particular, vaccinated patients had significantly higher lowest WBC, lower neutrophils, lower lymphocytes and lower CRP values than non-vaccinated patients (p < 0.05). After stratifying patients by breakthrough infection, those with breakthrough pneumococcal infection with vaccine coverage serotypes had more severe pneumonia disease (p < 0.05).
Conclusion: Systematic childhood pneumococcal vaccination reduced the prevalence of community-acquired pneumococcal pneumonia, especially in 2-5 year group. Serotype 19A was the major serotype for all vaccine types in patients with pneumococcal pneumonia and severity of acute inflammatory response was reduced in vaccinated patients.
Databáze: MEDLINE
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