Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines.

Autor: Birari L; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Shirpur, 425405, Maharashtra, India., Wagh S; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Shirpur, 425405, Maharashtra, India., Patil KR; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Shirpur, 425405, Maharashtra, India., Mahajan UB; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Shirpur, 425405, Maharashtra, India., Unger B; Pharmacology and Toxicology Division, ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, India., Belemkar S; School of Pharmacy and Technology Management, SVKM & NMIMS, MPTP, Dist. Dhule, Shirpur, 425405, Maharashtra, India., Goyal SN; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, 424001, Maharashtra, India., Ojha S; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 17666, Abu Dhabi, UAE., Patil CR; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Dist. Dhule, Shirpur, 425405, Maharashtra, India. xplore.remedies@gmail.com.
Jazyk: angličtina
Zdroj: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2020 Sep; Vol. 86 (3), pp. 419-426. Date of Electronic Publication: 2020 Aug 18.
DOI: 10.1007/s00280-020-04125-w
Abstrakt: Purpose: Aloin, an anthraquinone present in the aloe species, possesses antiangiogenic, chemopreventive and antioxidant properties. It exerts cytotoxicity against breast cancer and ovarian cancer cell lines. These properties of aloin project it as a chemopreventive adjuvant to anticancer chemotherapy.
Methods: We evaluated the effect of concurrent oral administration of aloin against doxorubicin (DOX)-induced cardiotoxicity in rats. The protective effects of aloin against DOX-induced toxicity were evident as a statistically significant inhibition of a rise in the biochemical markers of myocardial damage including lactate dehydrogenase (LDH), creatinine kinase-myocardial band (CK-MB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST).
Results: Aloin dose dependently inhibited the DOX-induced changes in ECG like increased ST-height and prolonged QT interval. It protected heart against the lipid peroxidation and restored the levels of antioxidative defenses: reduced glutathione, catalase and superoxide dismutase. Aloin prominently reduced the levels of proinflammatory cytokines- TNF-α, IL-1β and IL-6. Notably, the significant protective effects of aloin were evident even at the strikingly lower doses of 1 and 5 mg/kg per day.
Conclusion: Our results highlight the necessity to further investigate the chemopreventive effects of aloin against other chemotherapeutic agents.
Databáze: MEDLINE
Externí odkaz: