Cardiovascular risk and validation of cardiovascular risk prediction functions in a cohort of patients with type 2 diabetes followed for 10 years in Badajoz (SPAIN). AN observational study.

Autor: Calvo-Hueros JI; Hospital 'Nuestra Señora del Perpetuo Socorro', Servicio Extremeño de Salud, Badajoz, Spain. Electronic address: jich@hotmail.com., Cañón-Barroso L; Hospital Universitario, Servicio Extremeño de Salud, Badajoz, Spain. Electronic address: canonbarroso@yahoo.es., Morales-Gabardino JA; Unidad Medicalizada de Emergencia, Servicio Extremeño de Salud, Badajoz, Spain. Electronic address: vocalresidentes.sexmfyc@gmail.com., Buitrago F; Centro de Salud Universitario 'La Paz', Unidad Docente de Medicina Familiar y Comunitaria, Facultad de Medicina, Universidad de Extremadura, Servicio Extremeño de Salud, Badajoz, Spain. Electronic address: fbuitragor@gmail.com.
Jazyk: angličtina
Zdroj: Primary care diabetes [Prim Care Diabetes] 2021 Feb; Vol. 15 (1), pp. 115-120. Date of Electronic Publication: 2020 Aug 15.
DOI: 10.1016/j.pcd.2020.07.014
Abstrakt: Aims: To analyse whether diabetes behaves as an equivalent of coronary risk and assess the performance of the original and REGICOR Framingham functions in a cohort of patients with type 2 diabetes observed for 10 years in primary care practices in Badajoz, Spain.
Methods: Observational, longitudinal study. A total of 643 patients (mean age 64.0 years, 55.7% women), without evidence of cardiovascular disease were studied. We assessed the incidence of cardiovascular events and the patients' 10-year coronary risk predicted-values at the time of their recruitment.
Result: The actual incidence rate of coronary events was 14.5% (15.1% in women and 13.7% in men, p = 0.616). Patients who suffered coronary events were older (66.3 vs 63.6 years, p < 0.05), had higher total cholesterol (236.3 vs 219.5 mg/dl, p < 0.01), fasting plasma glucose levels (177.6 vs 159.8 mg/dl, p < 0.01), glycated haemoglobin (7.3 vs 6.7%, p < 0.05) and also higher prevalence of high blood pressure, dyslipidemia and chronic renal disease. The original Framingham equation overpredicted risk by 88%, whereas the REGICOR Framingham function underpredicted risk by 24%.
Conclusions: Diabetes in our cohort does not behave as a coronary heart disease equivalent and both the original and REGICOR Framingham coronary risk functions have little utility in a diabetic population.
(Copyright © 2020 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: