Association between intracranial aneurysm and meningiomas: An integrative survival Analysis with identification of prognostic factors.

Autor: de Souza MR; Mato Grosso State University, Mato Grosso, Tancredo Neves Avenue, 1095, Cáceres, State of Mato Grosso, 78200-000, Brazil., Fagundes CF; Mato Grosso State University, Mato Grosso, Tancredo Neves Avenue, 1095, Cáceres, State of Mato Grosso, 78200-000, Brazil., Rabelo NN; Department of Neurosurgery, Santa Casa Hospital, Saudade Avenue, 456, Ribeirão Preto, State of São Paulo, 14085-000, Brazil., Teixeira MJ; Department of Neurosurgery, Clinical Hospital, São Paulo University, USP, São Paulo, Brazil., Figueiredo EG; Department of Neurosurgery, Clinical Hospital, São Paulo University, USP, São Paulo, Brazil. Electronic address: ebgadelha@yahoo.com.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2020 Nov; Vol. 198, pp. 106128. Date of Electronic Publication: 2020 Aug 08.
DOI: 10.1016/j.clineuro.2020.106128
Abstrakt: Objective: To analyze prognostic factors in clinical association between intracranial aneurysm (IA) and meningioma. Prognostic factors on overall survival (OS) were evaluated.
Methods: We selected articles, published from January 1944 to December 2018 on the Medical databases (Web of Sciences, Medline and EMBASE) and included case series and reports. Clinical information was obtained and variables associated with the primary outcome of 27-mo survival were identified through Cox regression models.
Results: The study evaluated 77 patients. Female represented 76.6 % (n = 59), a ratio of 3.27 female: 1 male. The age range was 7-84 years old, with an average of 54.74 (SD: 14.30). Age and sex were not significant statistically different between the two groups for overall survival (OS) (log-rank P = 0.806), (log-rank P = 0.983) respectively. 77.9 % (n = 60) were ipsilateral, the same side was 4 times more common in univariate analysis (P = 0.052; 95 % CI, 0.924-17.319). Most aneurysms were detected in the internal carotid artery, 29.87 %. In Clinical data, 62.33 % (n = 48) had exclusive tumor symptoms, while 25.97 % (n = 20) presented exclusively subarachnoid hemorrhage (SAH). In multivariate analysis, although there is an independent protective factor for those who did not have SAH (HR; 0.099; CI; 0.010-0.986; P = 0.049) and the treatment is an independent predictor for OS (HR, 42.096; CI, 4.270-415.056; P = 0.01).
Conclusion: This is the first study to approach this association. This is not just an occasional finding, but it seems to have a shared pathophysiology. Unruptured aneurysms and treatment modality were protective independent factors for OS. Prospective studies are warranted to provide definitive answers.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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