Novel cardiac cell subpopulations: Pnmt-derived cardiomyocytes.

Autor:	Grassam-Rowe A; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK., Ou X; Key Laboratory of Medical Electrophysiology of the Ministry of Education and Institute of Cardiovascular Research, Southwest Medical University, Luzhou 6400, People's Republic of China., Lei M; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.; Key Laboratory of Medical Electrophysiology of the Ministry of Education and Institute of Cardiovascular Research, Southwest Medical University, Luzhou 6400, People's Republic of China.
Jazyk:	angličtina
Zdroj:	Open biology [Open Biol] 2020 Aug; Vol. 10 (8), pp. 200095. Date of Electronic Publication: 2020 Aug 19.
DOI:	10.1098/rsob.200095
Abstrakt:	Diversity among highly specialized cells underlies the fundamental biology of complex multi-cellular organisms. One of the essential scientific questions in cardiac biology has been to define subpopulations within the heart. The heart parenchyma comprises specialized cardiomyocytes (CMs). CMs have been canonically classified into a few phenotypically diverse subpopulations largely based on their function and anatomic localization. However, there is growing evidence that CM subpopulations are in fact numerous, with a diversity of genetic origin and putatively different roles in physiology and pathophysiology. In this chapter, we introduce a recently discovered CM subpopulation: phenylethanolamine- N -methyl transferase (Pnmt)-derived cardiomyocytes (PdCMs). We discuss: (i) canonical classifications of CM subpopulations; (ii) discovery of PdCMs; (iii) Pnmt and the role of catecholamines in the heart; similarities and dissimilarities of PdCMs and canonical CMs; and (iv) putative functions of PdCMs in both physiological and pathological states and future directions, such as in intra-cardiac adrenergic signalling.
Databáze:	MEDLINE
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