Changes in Seroprevalence of Helicobacter pylori Infection over 20 Years in Jinju, Korea, from Newborns to the Elderly.

Autor:	Park JS; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Jun JS; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Ryu EY; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Yeom JS; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Park ES; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Seo JH; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Lim JY; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Park CH; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Woo HO; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea., Baik SC; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.; Department of Microbiology, Gyeongsang National University College of Medicine, Jinju, Korea., Lee WK; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.; Department of Microbiology, Gyeongsang National University College of Medicine, Jinju, Korea., Cho MJ; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.; Department of Microbiology, Gyeongsang National University College of Medicine, Jinju, Korea., Rhee KH; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.; Department of Microbiology, Gyeongsang National University College of Medicine, Jinju, Korea., Youn HS; Department of Pediatrics, Gyeongsang National University College of Medicine and Gyeongsang National University Hospital, Jinju, Korea.; Institute of Health Sciences, Gyeongsang National University, Jinju, Korea. hsyoun@gnu.ac.kr.
Jazyk:	angličtina
Zdroj:	Journal of Korean medical science [J Korean Med Sci] 2020 Aug 17; Vol. 35 (32), pp. e259. Date of Electronic Publication: 2020 Aug 17.
DOI:	10.3346/jkms.2020.35.e259
Abstrakt:	Background: The objective of this study was to examine changes in the prevalence of cytotoxic-associated gene A (CagA) positive Helicobacter pylori infection in Jinju, Korea, over the last 20 years. Methods: Three cross-sectional analyses were conducted concurrently. A total of 1,305 serum samples were collected from 1994-1995, 2004-2005, and 2014-2015, respectively. The presence of immunoglobulin (Ig) G, IgA, and IgM antibodies against H. pylori CagA protein was examined by western blotting. Results: Overall, seropositivity for anti-CagA IgG antibody was significantly decreased from 63.2% to 42.5% over the last 20 years ( P < 0.001). Anti-CagA IgG seropositivities in children and young adults aged 10-29 years decreased from 1994 (60.0%-85.0%) to 2015 (12.5%-28.9%). The age when plateau of increasing IgG seropositivity was reached in each study period shifted from the 15-19 year-old group in 1994-1995 (85.0%) to the 40-49 year-old group in 2014-2015 (82.5%). Overall seropositive rates of anti-CagA IgA and IgM antibodies did not change significantly either over the last 20 years. Conclusion: H. pylori infection rate in children and young adults declined over 20 years in Jinju, probably due to improved sanitation, housing, or economy. Competing Interests: The authors have no potential conflicts of interest to disclose. (© 2020 The Korean Academy of Medical Sciences.)
Databáze:	MEDLINE
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