Platelet-rich plasma fibrin glue for treatment of chylothorax following cavopulmonary connections.

Autor:	Tashnizi MA; Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Maleki MH; Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Javedanfar O; Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Damsaz M; Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran., Alamdari AH; Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran., Seifalian AM; Nanotechnology and Regenerative Medicine Commercialisation Centre, London BioScience Innovation Centre, London, UK., Asadi M; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Hamidi Alamdari D; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Jazyk:	angličtina
Zdroj:	European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery [Eur J Cardiothorac Surg] 2020 Dec 01; Vol. 58 (6), pp. 1269-1273.
DOI:	10.1093/ejcts/ezaa243
Abstrakt:	Objectives: The postoperative persistence of chylothorax is a fatal complication of paediatric cardiac surgery. There is an urgent need for an effective treatment of chylothorax. This study reports the application of allogenic platelet-rich plasma fibrin glue (PRP-FG) as a conservative therapy before reoperation. Methods: Over a 9-year period, from 2010 to 2019, 27 patients with persistent chylothorax following a cavopulmonary connection, with a mean latency period of 11 days (range 10-15 days), were treated with PRP-FG. These patients were selected because they had not responded positively to initial conservative management plans. The patients were followed up for 9 years. Results: Twenty-five patients (92%) responded positively to treatment with PRP-FG; 2 patients did not respond to the treatment and died after reoperation. All of the successfully treated patients in follow-up continued to live a healthy life without further complications. Conclusions: Recalcitrant chylothorax that persists after paediatric cardiac surgery responded positively to treatment with PRP-FG. This technique precluded the need for another operation and significantly decreased the morbidity and mortality rates. (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
Databáze:	MEDLINE
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