Titanium coating with mussel inspired polymer and bio-orthogonal chemistry enhances antimicrobial activity against Staphylococcus aureus.

Autor: Czuban M; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany; Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. Electronic address: magdalena.czuban@charite.de., Kulka MW; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany., Wang L; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Center for Musculoskeletal Surgery, Berlin, Germany., Koliszak A; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Achazi K; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany., Schlaich C; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany., Donskyi IS; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany; BAM-Federal Institute for Material Science and Testing Division of Surface Analysis and Interfacial Chemistry, Berlin, Germany., Di Luca M; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Mejia Oneto JM; Shasqi Inc., San Francisco, United States., Royzen M; University at Albany, Department of Chemistry, Albany, NY, United States. Electronic address: mroyzen@albany.edu., Haag R; Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. Electronic address: haag@chemie.fu-berlin.de., Trampuz A; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Center for Musculoskeletal Surgery, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. Electronic address: andrej.trampuz@charite.de.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Nov; Vol. 116, pp. 111109. Date of Electronic Publication: 2020 May 21.
DOI: 10.1016/j.msec.2020.111109
Abstrakt: Implant-associated infections present severe and difficult-to-treat complications after surgery, related to implant biofilm colonization. Systemic administration of antibiotics cannot reach sufficient concentrations at the infected site and may be toxic. Here we describe how mussel-inspired dendritic material coated on a titanium surface can locally activate a prodrug of daptomycin (pro-dapto) to treat methicillin-resistant Staphylococcus aureus. The mechanism of the prodrug activation is based on bio-orthogonal click chemistry between a tetrazine (Tz) and trans-cyclooctene (TCO). The former is attached to the dendritic polymer, while the later converts daptomycin into a prodrug. Characterization of the material's properties revealed that it is hydrophobic, non-toxic, and stable for a prolonged period of time. We envision that the titanium coated dendritic material will be able to improve the treatment of implant-associated infections by concentrating systemically administered antibiotic prodrugs, thus converting them into active localized medicines.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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