Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value: A Multicentric 11C-Methionine and 18F-FDOPA PET Experience.
| Autor: | Zaragori T, Castello A; Nuclear Medicine Department, Humanitas Clinical and Research Hospital-IRCCS, Rozzano, Italy., Guedj E, Girard A; Department of Nuclear Medicine, Eugène Marquis Center, Rennes 1 University, Rennes, France., Galldiks N, Albert NL; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Lopci E; Nuclear Medicine Department, Humanitas Clinical and Research Hospital-IRCCS, Rozzano, Italy., Verger A |
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| Jazyk: | angličtina |
| Zdroj: | Clinical nuclear medicine [Clin Nucl Med] 2021 Jan; Vol. 46 (1), pp. e36-e37. |
| DOI: | 10.1097/RLU.0000000000003240 |
| Abstrakt: | The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-MET and F-FDOPA PET amino acid tracers. Thirty-two C-MET and 26 F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-MET and 10 F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047). |
| Databáze: | MEDLINE |
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