| Autor: |
Lewandowicz-Uszyńska A; Third Department and Clinic of Pediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, Wroclaw, Poland. aleksandra.lewandowicz-uszynska@umed.wroc.p.; Department of Immunology and Pediatrics, The J. Gromkowski Provincial Hospital, Wroclaw, Poland. aleksandra.lewandowicz-uszynska@umed.wroc.p., Pasternak G; Third Department and Clinic of Pediatrics, Immunology and Rheumatology of Developmental Age, Wroclaw Medical University, Wroclaw, Poland., Świerkot J; Department and Clinic of Rheumatology and Internal Medicine, Wroclaw Medical University, Wroclaw, Poland., Bogunia-Kubik K; Laboratory of Clinical Immunogenetics and Pharmacogenetics, The Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. |
| Abstrakt: |
Primary immunodeficiencies (PIDs) belong to a group of rare congenital diseases occurring all over the world that may be seen in both children and adults. In most cases, genetic predispositions are already known. As shown in this review, genetic abnormalities may be related to dysfunction of the immune system, which manifests itself as recurrent infections, increased risk of cancer, and autoimmune diseases. This article reviews the various forms of PIDs, including their characterization, management strategies, and complications. Novel aspects of the diagnostics and monitoring of PIDs are presented. |
