Reduced dengue incidence following deployments of Wolbachia -infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis.

Autor:	Indriani C; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Department of Epidemiology Biostatistics and Public Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Tantowijoyo W; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Rancès E; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., Andari B; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Prabowo E; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Yusdi D; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Ansari MR; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wardana DS; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Supriyati E; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Nurhayati I; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Ernesia I; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Setyawan S; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Fitriana I; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Arguni E; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Department of Paediatrics, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Amelia Y; Yogyakarta City Health Office, Yogyakarta, Indonesia., Ahmad RA; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Department of Epidemiology Biostatistics and Public Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Jewell NP; Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, USA.; Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, UK., Dufault SM; Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, USA., Ryan PA; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., Green BR; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., McAdam TF; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., O'Neill SL; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., Tanamas SK; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., Simmons CP; Institute of Vector Borne Disease, Monash University, Melbourne, Australia.; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Anders KL; Institute of Vector Borne Disease, Monash University, Melbourne, Australia., Utarini A; Centre of Tropical Medicine, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.; Department of Health Policy and Management, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Jazyk:	angličtina
Zdroj:	Gates open research [Gates Open Res] 2020 May 11; Vol. 4, pp. 50. Date of Electronic Publication: 2020 May 11 (Print Publication: 2020).
DOI:	10.12688/gatesopenres.13122.1
Abstrakt:	Background: Ae. aegypti mosquitoes stably transfected with the intracellular bacterium Wolbachia pipientis ( w Mel strain) have been deployed for biocontrol of dengue and related arboviral diseases in multiple countries. Field releases in northern Australia have previously demonstrated near elimination of local dengue transmission from Wolbachia -treated communities, and pilot studies in Indonesia have demonstrated the feasibility and acceptability of the method. We conducted a quasi-experimental trial to evaluate the impact of scaled Wolbachia releases on dengue incidence in an endemic setting in Indonesia. Methods: In Yogyakarta City, Indonesia, following extensive community engagement, w Mel Wolbachia -carrying mosquitoes were released every two weeks for 13-15 rounds over seven months in 2016-17, in a contiguous 5 km 2 area (population 65,000). A 3 km 2 area (population 34,000) on the opposite side of the city was selected a priori as an untreated control area. Passive surveillance data on notified hospitalised dengue patients was used to evaluate the epidemiological impact of Wolbachia deployments, using controlled interrupted time-series analysis. Results: Rapid and sustained introgression of w Mel Wolbachia into local Ae. aegypti populations was achieved. Thirty-four dengue cases were notified from the intervention area and 53 from the control area (incidence 26 vs 79 per 100,000 person-years) during 24 months following Wolbachia deployment. This corresponded in the regression model to a 73% reduction in dengue incidence (95% confidence interval 49%,86%) associated with the Wolbachia intervention. Exploratory analysis including 6 months additional post-intervention observations showed a small strengthening of this effect (30 vs 115 per 100,000 person-years; 76% reduction in incidence, 95%CI 60%,86%). Conclusions: We demonstrate a significant reduction in dengue incidence following successful introgression of Wolbachia into local Ae. aegypti populations in an endemic setting in Indonesia. These findings are consistent with previous field trials in northern Australia, and support the effectiveness of this novel approach for dengue control. Competing Interests: No competing interests were disclosed. (Copyright: © 2020 Indriani C et al.)
Databáze:	MEDLINE
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