Manganese-induced neurodegenerative diseases and possible therapeutic approaches.
| Autor: | Martins AC Jr; Department of Molecular Pharmacology, Albert Einstein College of Medicine , Bronx, NY, USA., Gubert P; Department of Biochemistry, Laboratory of Immunopathology Keizo Asami, LIKA, Federal, University of Pernambuco , Recife, Brazil.; Postgraduate Program in Pure and Applied Chemistry, Federal University of Western of Bahia , Bahia, Brazil., Villas Boas GR; Research Group on Development of Pharmaceutical Products (P&DProFar), Center for Biological and Health Sciences, Federal University of Western Bahia , Barreiras, Brazil., Meirelles Paes M; Research Group on Development of Pharmaceutical Products (P&DProFar), Center for Biological and Health Sciences, Federal University of Western Bahia , Barreiras, Brazil., Santamaría A; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía , Mexico City, Mexico., Lee E; Department of Pharmaceutical Sciences, Florida A&M University , Tallahassee, FL, USA., Tinkov AA; IM Sechenov First Moscow State Medical University (Sechenov University) , Moscow, Russia.; Yaroslavl State University , Yaroslavl, Russia.; Federal Research Centre of Biological Systems and Agro-Technologies of the Russian Academy of Sciences , Orenburg, Russia., Bowman AB; School of Health Sciences, Purdue University , West Lafayette, IN, USA., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine , Bronx, NY, USA.; IM Sechenov First Moscow State Medical University (Sechenov University) , Moscow, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Expert review of neurotherapeutics [Expert Rev Neurother] 2020 Nov; Vol. 20 (11), pp. 1109-1121. Date of Electronic Publication: 2020 Sep 02. |
| DOI: | 10.1080/14737175.2020.1807330 |
| Abstrakt: | Introduction: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and prion disease represent important public health concerns. Exposure to high levels of heavy metals such as manganese (Mn) may contribute to their development. Areas Covered: In this critical review, we address the role of Mn in the etiology of neurodegenerative diseases and discuss emerging treatments of Mn overload, such as chelation therapy. In addition, we discuss natural and synthetic compounds under development as prospective therapeutics. Moreover, bioinformatic approaches to identify new potential targets and therapeutic substances to reverse the neurodegenerative diseases are discussed. Expert Opinion: Here, the authors highlight the importance of better understanding the molecular mechanisms of toxicity associated with neurodegenerative diseases, and the role of Mn in these diseases. Additional emphasis should be directed to the discovery of new agents to treat Mn-induced diseases, since present day chelator therapies have limited bioavailability. Furthermore, the authors encourage the scientific community to develop research using libraries of compounds to screen those compounds that show efficacy in regulating brain Mn levels. In addition, bioinformatics may provide novel insight for pathways and clinical treatments associated with Mn-induced neurodegeneration, leading to a new direction in Mn toxicological research. |
| Databáze: | MEDLINE |
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