EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution.

Autor:	Mescheriakova JY; From the Department of Neurology (J.Y.M., K.L.K.); Department of Viroscience (G.P.N., A.A.E.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands (J.Y.M., K.L.K.)., van Nierop GP; From the Department of Neurology (J.Y.M., K.L.K.); Department of Viroscience (G.P.N., A.A.E.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands (J.Y.M., K.L.K.)., van der Eijk AA; From the Department of Neurology (J.Y.M., K.L.K.); Department of Viroscience (G.P.N., A.A.E.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands (J.Y.M., K.L.K.)., Kreft KL; From the Department of Neurology (J.Y.M., K.L.K.); Department of Viroscience (G.P.N., A.A.E.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands (J.Y.M., K.L.K.). k.kreft@erasmusmc.nl., Hintzen RQ; From the Department of Neurology (J.Y.M., K.L.K.); Department of Viroscience (G.P.N., A.A.E.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; and Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, the Netherlands (J.Y.M., K.L.K.). k.kreft@erasmusmc.nl.
Jazyk:	angličtina
Zdroj:	Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2020 Aug 13; Vol. 7 (6). Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020).
DOI:	10.1212/NXI.0000000000000872
Abstrakt:	Objective: In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic loci on the antiviral IgG titers. Methods: IgG levels against EBNA-1 and varicella zoster virus (VZV) as control were measured. HLA-DRB1*1501 and HLA-A*02 tagging single-nucleotide polymorphisms (SNPs) were genotyped. We assessed the associations between these SNPs and antiviral IgG titers. Results: OR for abundant EBNA-1 IgG was the highest in patients with MS and intermediate in their siblings compared with spouses. We confirmed that HLA-DRB1*1501 is associated with abundant EBNA-1 IgG. After stratification for HLA-DRB1*1501 , the EBNA-1 IgG gradient was still significant in patients with MS and young siblings compared with spouses. HLA-A*02 was not explanatory for EBNA-1 IgG titer gradient. No associations for VZV IgG were found. Conclusions: In families with MS, the EBNA-1 IgG gradient being the highest in patients with MS, intermediate in their siblings, and lowest in biologically unrelated spouses indicates a genetic contribution to EBNA-1 IgG levels that is only partially explained by HLA-DRB1*1501 carriership. (Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
Databáze:	MEDLINE
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