Skin conductance response and emotional response in women with psychogenic non-epileptic seizures.

Autor: Herrero H; Groupe Hospitalier Paul Guiraud, 94800 Villejuif, France; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France., Tarrada A; Service de Neurologie, CHRU Nancy Nancy, France., Haffen E; Inserm, EA 481Neurosciences,Department of Clinical Psychiatry, Besançon, France., Mignot T; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France., Sense C; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France., Schwan R; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France., El-Hage W; INSERM CIC 1415, Université de Tours, Tours, France., Maillard L; Service de Neurologie, CHRU Nancy Nancy, France; CNRS, CRAN - UMR 7039, Nancy F-54000, France., Hingray C; Pôle Universitaire du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; Service de Neurologie, CHRU Nancy Nancy, France.
Jazyk: angličtina
Zdroj: Seizure [Seizure] 2020 Oct; Vol. 81, pp. 123-131. Date of Electronic Publication: 2020 Jul 30.
DOI: 10.1016/j.seizure.2020.07.028
Abstrakt: Purpose: Recent etiopathogenic models place emotional dysregulation at the core of psychogenic nonepileptic seizure (PNES). Our purpose was to assess physiological, cognitive, and behavioral emotional responses of PNES patients.
Methods: This study compared three types of emotional responses to visual emotional stimuli between 34 female PNES group and 34 matched healthy controls: physiological response measured by skin conductance response (SCR) (rate, amplitude and latency) and heart rate deceleration; cognitive response measured by valence and arousal elicited by the images; and behavioural response measured by latency of ratings. The groups were characterized on psychiatric comorbidities, traumatic history, alexithymia, and dissociation.
Results: Compared to controls, PNES group displayed lower SCR for all images (p = 0.038), shorter amplitude of heart rate deceleration (p = 0.024) and faster arousal rating for all images (p = 0.019), but no difference on cognitive rating of images. Within-groups analyses showed only in PNES subjects increased rate (+19.35%, p = 0.046) SCR for negative stimuli with strong arousal compared to negative with low arousal. PNES physiological response (SCR and heart rate deceleration) was negatively correlated to dissociation tendency (r=-0.48, p = 0.0083) and alexithymia (r=-0.44, p = 0.012)). For cognitive response, no correlation was found.
Conclusion: These results are in favour of a lower physiological emotional response but with an over-reactivity at behavioral level contrasting with similar cognitive assessment. For strong aversive stimuli, PNES might present a trend to overreact at physiological and behavioural levels. Our results suggest that dissociation and difficulty in describing feelings are associated with an altered physiological response in PNES women only.
(Copyright © 2020 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: