Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance.

Autor: Brice KN; Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA., Hagen CW; Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA., Peterman JL; Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA., Figg JW; Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA., Braden PN; Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA., Chumley MJ; Texas Christian University, Department of Biology, 2955 South University Drive, Fort Worth, TX 76109, USA., Boehm GW; Texas Christian University, Department of Psychology, 2955 South University Drive, Fort Worth, TX 76109, USA. Electronic address: g.boehm@tcu.edu.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2020 Nov 01; Vol. 226, pp. 113128. Date of Electronic Publication: 2020 Aug 11.
DOI: 10.1016/j.physbeh.2020.113128
Abstrakt: Currently, over 44 million people worldwide suffer from Alzheimer's disease (AD). A common feature of AD is disrupted sleep. Sleep is essential for many psychological and physiological functions, though 35.3% of adults report getting less than 7 hours per night. The present research examined whether chronic sleep restriction would elevate hippocampal amyloid-beta 1-42 expression or alter cognitive ability in adult C57BL/6 mice. Chronic sleep restriction was associated with cognitive impairment and increased hippocampal amyloid-beta. Thus, chronic sleep loss may have a detrimental effect upon cognitive function, in part, via increasing amyloid-beta levels in the hippocampus, even in non-genetically modified mice.
Competing Interests: Declaration of Competing Interests None.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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