Epidemiology of haematological malignancies in people living with HIV.

Autor:	Kimani SM; Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; University of North Carolina Project-Malawi, Lilongwe, Malawi., Painschab MS; Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; University of North Carolina Project-Malawi, Lilongwe, Malawi., Horner MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Muchengeti M; National Health Laboratory Service, Johannesburg, South Africa., Fedoriw Y; Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; University of North Carolina Project-Malawi, Lilongwe, Malawi., Shiels MS; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Gopal S; Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; University of North Carolina Project-Malawi, Lilongwe, Malawi. Electronic address: satish_gopal@med.unc.edu.
Jazyk:	angličtina
Zdroj:	The lancet. HIV [Lancet HIV] 2020 Sep; Vol. 7 (9), pp. e641-e651. Date of Electronic Publication: 2020 Aug 10.
DOI:	10.1016/S2352-3018(20)30118-1
Abstrakt:	People living with HIV or AIDS are at increased risk of Hodgkin and non-Hodgkin lymphoma compared with HIV-negative individuals. Data on the risk of multiple myeloma or leukaemia are inconsistent and of low quality but the risk does not seem to be increased. Specific haematological malignancies occur in different contexts of age, CD4 cell count, HIV control, viral co-infections, or chronic inflammation, and the expansion of combination antiretroviral therapy has led to varied demographic and epidemiological shifts among people with HIV. Increased use of combination antiretroviral therapy has substantially reduced the risks of diffuse large B-cell lymphoma, Burkitt lymphoma, and primary CNS lymphoma, and to a lesser extent, Hodgkin lymphoma. There is no effect of combination antiretroviral therapy use on multiple myeloma or leukaemia. Although many cases of HIV are in low-income and middle-income countries, high-quality epidemiological data for haematological malignancies from these regions are scarce. Closing this gap is an essential first step in decreasing mortality from HIV-associated haematological malignancies worldwide. Finally, although multicentric Castleman disease is not a neoplastic condition, it is an emerging precursor to neoplastic high-grade B-cell lymphoproliferation among people with HIV, especially for individuals on long-term combination antiretroviral therapy with well controlled HIV. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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