Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.
| Autor: | Bravo Núñez MA; Stowers Institute for Medical Research, Kansas City, United States., Sabbarini IM; Stowers Institute for Medical Research, Kansas City, United States., Eide LE; Stowers Institute for Medical Research, Kansas City, United States.; University of Missouri-Kansas City, Kansas City, United States., Unckless RL; Department of Molecular Biosciences, University of Kansas, Lawrence, United States., Zanders SE; Stowers Institute for Medical Research, Kansas City, United States.; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, United States. |
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| Jazyk: | angličtina |
| Zdroj: | ELife [Elife] 2020 Aug 13; Vol. 9. Date of Electronic Publication: 2020 Aug 13. |
| DOI: | 10.7554/eLife.57936 |
| Abstrakt: | Killer meiotic drivers are genetic parasites that destroy 'sibling' gametes lacking the driver allele. The fitness costs of drive can lead to selection of unlinked suppressors. This suppression could involve evolutionary tradeoffs that compromise gametogenesis and contribute to infertility. Schizosaccharomyces pombe , an organism containing numerous gamete (spore)-killing wtf drivers, offers a tractable system to test this hypothesis. Here, we demonstrate that in scenarios analogous to outcrossing, wtf drivers generate a fitness landscape in which atypical spores, such as aneuploids and diploids, are advantageous. In this context, wtf drivers can decrease the fitness costs of mutations that disrupt meiotic fidelity and, in some circumstances, can even make such mutations beneficial. Moreover, we find that S. pombe isolates vary greatly in their ability to make haploid spores, with some isolates generating up to 46% aneuploid or diploid spores. This work empirically demonstrates the potential for meiotic drivers to shape the evolution of gametogenesis. Competing Interests: MB, SZ Inventor on a patent application based on wtf killers (patent application serial 62/491,107). IS, LE, RU No competing interests declared (© 2020, Bravo Núñez et al.) |
| Databáze: | MEDLINE |
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