Distribution of myocardial work in arterial hypertension: insights from non-invasive left ventricular pressure-strain relations.

Autor: Loncaric F; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain. loncaric.filip@gmail.com., Marciniak M; Department of Biomedical Engineering, Kings College London, London, UK., Nunno L; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain., Mimbrero M; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain., Fernandes JF; Department of Biomedical Engineering, Kings College London, London, UK., Fabijanovic D; University Hospital Centre Zagreb, Department for Cardiovascular Diseases and University of Zagreb School of Medicine, Zagreb, Croatia., Sanchis L; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain., Doltra A; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain., Montserrat S; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain.; CIBERCV, Instituto de Salud Carlos III (CB16/11/00354); CERCA Programme / Generalitat de Catalunya, Madrid, Spain., Cikes M; University Hospital Centre Zagreb, Department for Cardiovascular Diseases and University of Zagreb School of Medicine, Zagreb, Croatia., Lamata P; Department of Biomedical Engineering, Kings College London, London, UK., Bijnens B; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; La Institució Catalana de Recerca i Estudis Avançats, (ICREA), Barcelona, Spain., Sitges M; Institute of Biomedical Research August Pi Sunyer (IDIBAPS), Carrer del Rosselló, 149, 08036, Barcelona, Spain.; Cardiovascular Institute, Hospital Clínic and Universitat de Barcelona, Barcelona, Spain.; CIBERCV, Instituto de Salud Carlos III (CB16/11/00354); CERCA Programme / Generalitat de Catalunya, Madrid, Spain.
Jazyk: angličtina
Zdroj: The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2021 Jan; Vol. 37 (1), pp. 145-154. Date of Electronic Publication: 2020 Aug 12.
DOI: 10.1007/s10554-020-01969-4
Abstrakt: A index of non-invasive myocardial work (MWI) can account for pressure during the assessment of cardiac function, potentially separating the influence of loading conditions from the influence of the underlying tissue remodelling. The aim is to assess LV function accounted for loading and explore hypertensive MWI distribution by comparing healthy individuals to hypertensive patients without and with localized basal septal hypertrophy (BSH). An echocardiogram was performed in 170 hypertensive patients and 20 healthy individuals. BSH was defined by a basal-to-mid septal wall thickness ratio ≥ 1.4. LV speckle-tracking was performed, and the MWI calculated globally and regionally for the apical, mid and basal regions. An apex-to-base gradient, seen in regional strain values, was preserved in the distribution of myocardial work, with the apical region compensating for the impairment of the basal segments. This functional redistribution was further pronounced in patients with localized BSH. In these patients, segmental MWI analysis revealed underlying impairment of regional work unrelated to acute loading conditions. Non-invasive MWI analysis offers the possibility to compare LV function regardless of blood pressure at the time of observation. Changes in MWI distribution can be seen in hypertension unrelated to the load-dependency of strain. Accentuated functional changes affirm the role of BSH as an echocardiographic marker in hypertension.
Databáze: MEDLINE
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