Baseline prevalence and type distribution of Human papillomavirus in sexually active non-vaccinated adolescent girls from Argentina.

Autor:	González JV; Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas - ANLIS 'Dr. Malbrán', Av. Velez Sarsfield 563, C1282AFF, Buenos Aires, Argentina., Deluca GD; Facultad de Medicina, Universidad Nacional del Nordeste, Mariano Moreno 1240, W3400ACX, Corrientes, Argentina., Liotta DJ; Laboratorio de Biología Molecular Aplicada, Facultad de Ciencias Exactas, Químicas y Naturales, Universidad Nacional de Misiones, Av. Mariano Moreno 1375, N3300, Posadas, Misiones, Argentina; Instituto Nacional de Medicina Tropical-ANLIS 'Dr. Malbrán', Neuquén y Jujuy s/n, N3370, Puerto Iguazú, Misiones, Argentina., Correa RM; Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas - ANLIS 'Dr. Malbrán', Av. Velez Sarsfield 563, C1282AFF, Buenos Aires, Argentina., Basiletti JA; Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas - ANLIS 'Dr. Malbrán', Av. Velez Sarsfield 563, C1282AFF, Buenos Aires, Argentina., Colucci MC; Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas - ANLIS 'Dr. Malbrán', Av. Velez Sarsfield 563, C1282AFF, Buenos Aires, Argentina., Katz N; Dirección de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, Rivadavia 875, C1002AAG, Buenos Aires, Argentina., Vizzotti C; Dirección de Control de Enfermedades Inmunoprevenibles, Ministerio de Salud de la Nación, Rivadavia 875, C1002AAG, Buenos Aires, Argentina., Picconi MA; Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas - ANLIS 'Dr. Malbrán', Av. Velez Sarsfield 563, C1282AFF, Buenos Aires, Argentina. Electronic address: mapicconi@anlis.gov.ar.
Jazyk:	angličtina
Zdroj:	Revista Argentina de microbiologia [Rev Argent Microbiol] 2021 Jan-Mar; Vol. 53 (1), pp. 11-19. Date of Electronic Publication: 2020 Aug 09.
DOI:	10.1016/j.ram.2020.06.004
Abstrakt:	In 2011, Argentina launched a government-funded national Human papillomavirus (HPV) immunization program incorporating a bivalent HPV vaccine, with a 0-1-6-month schedule, for girls 11 years of age, born after January 2000. Monitoring the changes of HPV infection prevalence among young women has been proposed as an endpoint for early assessment of HPV vaccination programs. However, the data on HPV prevalence at young ages are very limited. The aim of this work was to determine the prevalence of HPV infection and type-specific distribution in sexually active 15-17-year-old non-vaccinated girls. Cervical samples from 1073 adolescents were collected for HPV detection and genotyping using the BSGP5+/GP6+PCR-reverse line blot (RLB) assay. Out of 957 specimens analyzed, 56.3% were positive for any HPV type; 42.2% harbored at least one high-risk HPV (HR-HPV) type and 30.8% low-risk HPV (LR-HPV) types. Multiple and single infections were identified in 36.3% and 20.0% of the samples respectively. The 6 most common HR-HPV types were HPV16 (11.1%), HPV52 (10.8%), HPV56 (8.3%), HPV51 (7.4%), HPV58 (7.3%) and HPV31 (7.1%). The prevalence of HR-HPV-16/18 was 15.2%. In conclusion, results confirm that HPV (particularly HR-types) are very common among sexually active adolescents, and prevalence rises quickly after their sexual debut. Our HPV type-specific prevalence baseline may be used to monitor post-vaccinal longitudinal changes in Argentina. (Copyright © 2020 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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