| Autor: |
Su Y; Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou Key Medical Disciplines and Specialties Program, Guangzhou Key Laboratories, Guangzhou, China., Liu W; Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou Key Medical Disciplines and Specialties Program, Guangzhou Key Laboratories, Guangzhou, China., Dong G; Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, China., Qian Z; Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, 40272Saint Louis University, St. Louis, MO, USA., Gurram N; Department of Epidemiology and Biostatistics, School of Public Health, 1084University at Albany, State University of New York, Albany, NY, USA., Liu E; Department of Health Management and Policy, College for Public Health and Social Justice, 40272Saint Louis University, Saint Louis, MO, USA., Cummings-Vaughn LA; Department of Medicine, Division of Geriatrics and Nutritional Science, Saint Louis, MO, USA., Howard SW; Department of Health Management and Policy, College for Public Health and Social Justice, 40272Saint Louis University, Saint Louis, MO, USA., Vaughn MG; School of Social Work, College for Public Health & Social Justice, 40272Saint Louis University, Tegeler Hall, St. Louis, MO, USA., Jansson DR; Department of Epidemiology and Biostatistics, College for Public Health and Social Justice, 40272Saint Louis University, St. Louis, MO, USA., Zhang C; Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou Key Medical Disciplines and Specialties Program, Guangzhou Key Laboratories, Guangzhou, China., Wang J; Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou Key Medical Disciplines and Specialties Program, Guangzhou Key Laboratories, Guangzhou, China., Liu Y; Guangzhou Twelfth People's Hospital, Guangzhou Occupational Disease Prevention and Treatment Hospital, Guangzhou Key Medical Disciplines and Specialties Program, Guangzhou Key Laboratories, Guangzhou, China. |
| Abstrakt: |
Initial symptoms of paraquat (PQ) toxicity are often not obvious, and the lack of advanced testing equipment and medical conditions in the primary hospital make it difficult to provide early diagnosis and timely treatment. To explore simple, objective, and effective indicators of prognosis for primary clinicians, we retrospectively analyzed acute PQ poisoning in 190 patients admitted to our hospital from 2008 to 2017. Based on their condition at the time of discharge, patients were categorized into either the survival group ( n = 71) or the mortality group ( n = 119). Age, PQ ingested amount, urinary PQ, urinary protein, white blood cell (WBC), and serum creatinine (Cr) were the key factors associated with the prognosis for PQ poisoning. We identified specific diagnostic thresholds for these key indicators of PQ poisoning: PQ ingested amount (36.50 mL), urinary PQ (semiquantitative result "++"), urinary protein (semiquantitative result "±"), WBC (16.50 × 10 9 /L), and serum Cr (102.10 µmol/L). Combining these five indicators to identify poisoning outcomes was considered objective, accurate, and convenient. When the combined score was <1, the predicted probability of patient death was 6%. When the combined score was ≥3, the predicted probability of patient death was 96%. These findings provide metrics to assist primary clinicians in predicting outcomes of acute PQ poisoning at earlier stages, a basis for administering treatment. |
