| Autor: |
Jin Y; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China., Ding YH; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China., Dong JJ; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China., Wei Y; College of Chemistry & Pharmacy, Research Center of Agro-bionic Engineering & Technology of Shandong Province, Qingdao Agricultural University, Qingdao, China., Hao SH; College of Chemistry & Pharmacy, Research Center of Agro-bionic Engineering & Technology of Shandong Province, Qingdao Agricultural University, Qingdao, China., Feng BC; College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China. |
| Abstrakt: |
ABTRACTThis study aims to design and synthesize a series of N-Acyl-N-(m-fluoro- benzyl)-6- amino-coumarins through the principle of active substructure stitching, which are based on the core structure of N-(m-fluoro-benzyl)-6-amino-coumarin. The structures of target compounds e1-e25 have been characterized by 1 H NMR, 13 C NMR, ESI-MS and elemental analysis. Meanwhile, their agricultural activity have been evaluated in two weeds ( Amaranth and Crabgrass ) and four widespread noxious pathogens ( V.mali, B.cinerea, F.axysporium and C.bacteria ). The herbicidal activity results showed that almost all synthetic molecules have a greater impact on the stem system than on the root. Excellent inhibition rates were discovered from compounds e2-e5 and e20-e23 against Amaranth on stems, which were above 58%(20 mg/L), 68%(100 mg/L) respectively. Compounds e2 and e21 also exhibited striking inhibition on stems growth of both weeds. Anti-pathogenic activity showed that all the compounds exerted a better inhibitory activity on B.cinerea at 20 ppm compared to control carbendazim. All the heterocyclic substituted compounds ( e17-e24 , >57%) made a better influence than the control (54.1%) at the100 ppm. This research provides promising herbicidal and anti-pathogenic agents that have the better effects and can be potential for further development. |
