| Autor: |
Ramabulana T; Department of Chemistry, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Scheepers LM; Department of Chemistry, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Moodley T; Department of Chemistry, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Maharaj VJ; Department of Chemistry, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Stander A; Department of Physiology, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Gama N; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa., Ferreira D; Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States., Sonopo MS; Radiochemistry, South African Nuclear Energy Corporation (Necsa), Pelindaba, Brits, South Africa., Selepe MA; Department of Chemistry, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa. |
| Abstrakt: |
Phytochemical investigation of extracts of the stems of Hypoestes aristata led to the isolation of nine lignans that included four known compounds, namely, hinokinin ( 1 ), savinin ( 2 ), medioresinol ( 3 ), and two cubebins ( 8a , b ), three new butyrolactone lignans ( 4 - 6 ), and butyrolactol lignans 7a - c . The structures of the new compounds were established using 1D and 2D NMR and HRESIMS data. The absolute configurations of the new lignans were determined from their ECD data and the Mosher's ester method. This is the first unequivocal assignment of the absolute configuration at C-7 and C-7' of 7- and 7'-hydroxybutyrolactone lignans. The compounds were screened for inhibition of an HIV-1 protease enzyme, and compounds 1 and 6 exhibited moderate activity in this regard. |
